Copper and iron are essential but also toxic metals. Their essentiality is known, but their
toxicity, except for the genetic overload diseases, Wilson's disease and hemochromatosis, is …

Neurodegenerative diseases constitute a worldwide health problem. Metals like iron and
copper are essential for life, but they are also involved in several neurodegenerative …

J. Neurochem.(2010) 113, 1263–1274. Abstract Parkinson's disease is characterized by
deposition of misfolded/aggregated α‐synuclein proteins in multiple regions of the brain …

The aggregation of alpha-synuclein (AS) is a critical step in the etiology of Parkinson's
disease (PD). A central, unresolved question in the pathophysiology of PD relates to the role …

α-Synuclein (α-syn), a presynaptic protein believed to play an important role in
neuropathology in Parkinson's disease (PD), is known to bind Cu2+. Cu2+ has been shown …

J. Neurochem.(2010) 113, 704–714. Abstract Alpha‐synuclein is a natively unfolded protein
that aggregates and forms inclusions that are associated with a range of diseases that …

Significant evidence has been accumulated linking exposure to heavy metals and/or
distortion of metal homeostasis with the development of various neurodegenerative …

Dyshomeostasis of transition metals iron and copper as well as accumulation of oxidative
DNA damage have been implicated in multitude of human neurodegenerative diseases …

Alpha‐synuclein is a natively unfolded protein associated with a number of
neurodegenerative disorders that include Parkinson's disease. In the past, research has …

Neurodegenerative diseases include Alzheimer's and Parkinson's disease that are very
common and other diseases that are notorious but occur less often such as Creutzfeldt …