Cardiovascular disease constitutes a major and increasing health burden in developed
countries. Although treatments have progressed, the development of novel treatments for …

Obesity, a highly prevalent condition, is heterogeneous with regard to its impact on
cardiovascular disease (CVD) risk. Epidemiological observations and metabolic …

Purpose To evaluate the prevalence of cardiovascular risk factors and long-term incidence
of cardiovascular disease (CVD) in survivors of testicular cancer (TC). Methods Overall, 990 …

Rationale: Angiotensin-converting enzyme (ACE) 2 opposes the actions of angiotensin
(Ang) II by degrading it to Ang 1-7. Objective: Given the important role of Ang II/Ang 1-7 in …

The endothelium is a delicate monolayer of cells that lines all blood vessels, and which
comprises the systemic and lymphatic capillaries. By virtue of the panoply of paracrine …

Objectives: The purpose of this study was to summarize the evidence of pre-procedural
statin therapy to reduce periprocedure cardiovascular events. Background: Invasive …

Persistent inflammation underlies many prevalent diseases including atherosclerosis and
diabetes. There is a growing appreciation that inflammation and its active resolution may be …

Danshen, the dried root of Salvia miltiorrhiza, is a Chinese medicine used to promote blood
flow and treat vascular disease. The present article reviews the pharmacological effects of …

This review focuses on the non-statin strategies for the treatment of hyperlipidemias in
humans. Even if statins remain the major hypolipidemic drugs at present, an increasing …

Rationale: Thrombospondin (TSP)-4 is an extracellular protein that has been linked to
several cardiovascular pathologies. However, a role for TSP-4 in vascular wall biology …