Myeloproliferative neoplasms (MPNs) originate from genetically transformed hematopoietic
stem cells that retain the capacity for multilineage differentiation and effective myelopoiesis …

Single nucleotide polymorphism arrays (SNP-A) have recently been widely applied as a
powerful karyotyping tool in numerous translational cancer studies. SNP-A complements …

CBL encodes a member of the Cbl family of proteins, which functions as an E3 ubiquitin
ligase. We describe a dominant developmental disorder resulting from germline missense …

RAS signaling plays a key role in controlling appropriate cell responses to extracellular
stimuli and participates in early and late developmental processes. Although enhanced flow …

Background CBL missense mutations have recently been associated with juvenile
myelomonocytic leukaemia (JMML), an aggressive myeloproliferative and myelodysplastic …

Cbl was originally discovered in 1989 as the cellular homolog of the v-Cbl oncogene, the
transforming gene of the Cas NS-1 murine retrovirus that causes myeloid leukemia and …

Oncogenic NRAS mutations are frequently identified in myeloid diseases involving
monocyte lineage. However, its role in the genesis of these diseases remains elusive. We …

Although myeloid leukemias are primarily caused by leukemic stem cells, the molecular
basis of their transformation remains largely unknown. Here, by analyzing mice with a …

Abstract Mutant Fms-Like Tyrosine kinase-3 (FLT3), which is expressed in the leukemic cells
of a subpopulation of acute myeloid leukemia (AML) patients, represents an attractive target …

Juvenile myelomonocytic leukemia (JMML) is a rare pediatric myeloid neoplasm
characterized by excessive proliferation of myelomonocytic cells. When we investigated the …