Simulation of gastrointestinal conditions is essential to adequately predict the in vivo
behavior of drug formulations. To reduce the size and number of human studies required to …

Self-emulsifying drug delivery systems are a vital tool in solving low bioavailability issues of
poorly soluble drugs. Hydrophobic drugs can be dissolved in these systems, enabling them …

The main aim of pharmaceutical technology research is the design of successful
formulations for effective therapy, taking into account several issues including therapeutic …

Purpose: Nanoparticle engineering offers promising methods for the formulation of poorly
water soluble drug compounds. The aim of the present work was to enhance dissolution and …

Dissolution tests that can predict the in vivo performance of drug products are usually called
biorelevant dissolution tests. Biorelevant dissolution testing can be used to guide …

This study coupled results from biorelevant dissolution tests with in silico simulation
technology to forecast in vivo oral absorption of micronized and nanosized aprepitant …

Surface functionalized mesoporous silicon (pSi) microparticles are reported as a solid
dispersion carrier for improving dissolution and enhancing the orally administered …

Purpose To investigate the effect of crystal size on the dissolution and oral absorption of
nitrendipine, a poorly soluble drug, in rats. Methods Five types of nitrendipine crystal …

Micelles formed in the GI tract by bile acid and lecithin play an important role in oral
absorption of poorly soluble drugs. In this situation, the drug molecules are present in …

The purpose of this study is to clarify the effects of intestinal drug supersaturation on
solubility-limited nonlinear absorption. Oral absorption of a novel farnesyltransferase …