The Use of Biorelevant Dissolution Media to Forecast the In Vivo Performance of a Drug
S Klein - The AAPS journal, 2010 - Springer
Simulation of gastrointestinal conditions is essential to adequately predict the in vivo
behavior of drug formulations. To reduce the size and number of human studies required to …
behavior of drug formulations. To reduce the size and number of human studies required to …
Self-emulsifying drug delivery systems: an approach to enhance oral bioavailability
Self-emulsifying drug delivery systems are a vital tool in solving low bioavailability issues of
poorly soluble drugs. Hydrophobic drugs can be dissolved in these systems, enabling them …
poorly soluble drugs. Hydrophobic drugs can be dissolved in these systems, enabling them …
Lipid nanoparticles: effect on bioavailability and pharmacokinetic changes
EB Souto, RH Müller - Drug delivery, 2010 - Springer
The main aim of pharmaceutical technology research is the design of successful
formulations for effective therapy, taking into account several issues including therapeutic …
formulations for effective therapy, taking into account several issues including therapeutic …
Mechanism of dissolution enhancement and bioavailability of poorly water soluble celecoxib by preparing stable amorphous nanoparticles
Y Liu, C Sun, Y Hao, T Jiang… - Journal of pharmacy …, 2010 - journals.library.ualberta.ca
Purpose: Nanoparticle engineering offers promising methods for the formulation of poorly
water soluble drug compounds. The aim of the present work was to enhance dissolution and …
water soluble drug compounds. The aim of the present work was to enhance dissolution and …
Biorelevant dissolution methods and their applications in in vitro-in vivo correlations for oral formulations
N Fotaki, M Vertzoni - The Open Drug Delivery Journal, 2010 - benthamopen.com
Dissolution tests that can predict the in vivo performance of drug products are usually called
biorelevant dissolution tests. Biorelevant dissolution testing can be used to guide …
biorelevant dissolution tests. Biorelevant dissolution testing can be used to guide …
Forecasting in vivo oral absorption and food effect of micronized and nanosized aprepitant formulations in humans
Y Shono, E Jantratid, F Kesisoglou, C Reppas… - European journal of …, 2010 - Elsevier
This study coupled results from biorelevant dissolution tests with in silico simulation
technology to forecast in vivo oral absorption of micronized and nanosized aprepitant …
technology to forecast in vivo oral absorption of micronized and nanosized aprepitant …
Oxidized mesoporous silicon microparticles for improved oral delivery of poorly soluble drugs
Surface functionalized mesoporous silicon (pSi) microparticles are reported as a solid
dispersion carrier for improving dissolution and enhancing the orally administered …
dispersion carrier for improving dissolution and enhancing the orally administered …
Effect of Crystal Size on the In Vitro Dissolution and Oral Absorption of Nitrendipine in Rats
D Xia, F Cui, H Piao, D Cun, H Piao, Y Jiang… - Pharmaceutical …, 2010 - Springer
Purpose To investigate the effect of crystal size on the dissolution and oral absorption of
nitrendipine, a poorly soluble drug, in rats. Methods Five types of nitrendipine crystal …
nitrendipine, a poorly soluble drug, in rats. Methods Five types of nitrendipine crystal …
Mechanisms of membrane transport of poorly soluble drugs: role of micelles in oral absorption processes
K Yano, Y Masaoka, M Kataoka, S Sakuma… - Journal of …, 2010 - Elsevier
Micelles formed in the GI tract by bile acid and lecithin play an important role in oral
absorption of poorly soluble drugs. In this situation, the drug molecules are present in …
absorption of poorly soluble drugs. In this situation, the drug molecules are present in …
Quantitative analysis of the effect of supersaturation on in vivo drug absorption
R Takano, N Takata, R Saito, K Furumoto… - Molecular …, 2010 - ACS Publications
The purpose of this study is to clarify the effects of intestinal drug supersaturation on
solubility-limited nonlinear absorption. Oral absorption of a novel farnesyltransferase …
solubility-limited nonlinear absorption. Oral absorption of a novel farnesyltransferase …