Strategies for the design of bi-or multifunctional drugs are reviewed. A distinction is made
between bifunctional drugs interacting in a monovalent fashion with two targets and ligands …

Importance of the field: Discovery and synthesis of analgesic ligands can potentially improve
analgesia, reduce side effects, minimize psychologic dependence and delay analgesic …

Neuropathic pain states and tolerance to opioids can result from system changes in the
CNS, such as up-regulation of the NK1 receptor and substance P, lead to antiopioid effects …

Compounds containing TRPV6-binding peptides and their use in the detection and
diagnosis of cancer are described. Also described are methods for detecting and staging …

TRPV6-binding peptides derived from soricidin, and compounds or compositions thereof,
and their use in the detection and diagnosis of cancer are described. Also described are …

I would like to give my sincere appreciation to my advisor Regents professor Victor J Hruby
for his generous support in my projects. His scientific foresight, sagacity, and always positive …