Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP‐1c
P Ferre, F Foufelle - Diabetes, obesity and metabolism, 2010 - Wiley Online Library
Steatosis is an accumulation of triglycerides in the liver. Although an excessive availability of
plasma fatty acids is an important determinant of steatosis, lipid synthesis from glucose …
plasma fatty acids is an important determinant of steatosis, lipid synthesis from glucose …
The role of endoplasmic reticulum stress in the progression of atherosclerosis
I Tabas - Circulation research, 2010 - Am Heart Assoc
Prolonged activation of the endoplasmic reticulum (ER) stress pathway known as the
unfolded protein response (UPR) can lead to cell pathology and subsequent tissue …
unfolded protein response (UPR) can lead to cell pathology and subsequent tissue …
Endoplasmic reticulum stress and inflammation in obesity and diabetes
S Hummasti, GS Hotamisligil - Circulation research, 2010 - Am Heart Assoc
Obesity is a major problem worldwide that increases risk for a wide range of diseases,
including diabetes and heart disease. As such, it is increasingly important to understand …
including diabetes and heart disease. As such, it is increasingly important to understand …
Circadian clock-coordinated 12 hr period rhythmic activation of the IRE1α pathway controls lipid metabolism in mouse liver
G Cretenet, M Le Clech, F Gachon - Cell metabolism, 2010 - cell.com
The mammalian circadian clock plays a fundamental role in the liver by regulating fatty acid,
glucose, and xenobiotic metabolism. Impairment of this rhythm has been shown to lead to …
glucose, and xenobiotic metabolism. Impairment of this rhythm has been shown to lead to …
[PDF][PDF] Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol‐fed cystathionine beta synthase–deficient mouse
F Esfandiari, V Medici, DH Wong, S Jose… - …, 2010 - Wiley Online Library
We tested the hypothesis that the pathogenesis of alcoholic liver injury is mediated by
epigenetic changes in regulatory genes that result from the induction of aberrant methionine …
epigenetic changes in regulatory genes that result from the induction of aberrant methionine …
Translational control of the sterol-regulatory transcription factor SREBP-1 mRNA in response to serum starvation or ER stress is mediated by an internal ribosome …
F Damiano, S Alemanno, GV Gnoni… - Biochemical …, 2010 - portlandpress.com
SREBPs (sterol-regulatory-element-binding proteins) are a family of transcription factors that
modulate the expression of several enzymes implicated in endogenous cholesterol, fatty …
modulate the expression of several enzymes implicated in endogenous cholesterol, fatty …
Endoplasmic reticulum stress: a new actor in the development of hepatic steatosis
M Flamment, HL Kammoun, I Hainault… - Current opinion in …, 2010 - journals.lww.com
Manipulating endoplasmic reticulum stress pathway yields encouraging results for the
treatment of hepatic steatosis in rodents. However, activation of unfolded protein response is …
treatment of hepatic steatosis in rodents. However, activation of unfolded protein response is …
[HTML][HTML] Role of unfolded protein response in lipogenesis
Z Zheng, C Zhang, K Zhang - World journal of hepatology, 2010 - ncbi.nlm.nih.gov
The signal transduction network in regulating lipid metabolism is a hot topic of biomedical
research. Recent research endeavors reveal that intracellular stress signaling from a cellular …
research. Recent research endeavors reveal that intracellular stress signaling from a cellular …
Ethyl-eicosapentaenoate modulates changes in neurochemistry and brain lipids induced by parkinsonian neurotoxin 1-methyl-4-phenylpyridinium in mouse brain …
QJ Meng, DW Luchtman, B El Bahh… - European journal of …, 2010 - Elsevier
Evidence suggests a link between Parkinson's disease and the dietary intake of omega (n)−
3 and n− 6 polyunsaturated fatty acids (PUFAs). Presently, we investigated whether an acute …
3 and n− 6 polyunsaturated fatty acids (PUFAs). Presently, we investigated whether an acute …
[HTML][HTML] Lipids to the top of hair biology
KS Stenn, P Karnik - Journal of Investigative Dermatology, 2010 - Elsevier
Little attention has been given to the impact of lipid metabolism on hair follicle biology and
pathology. Three recent papers (one in the current issue) describe a major effect of altered …
pathology. Three recent papers (one in the current issue) describe a major effect of altered …