Steatosis is an accumulation of triglycerides in the liver. Although an excessive availability of
plasma fatty acids is an important determinant of steatosis, lipid synthesis from glucose …

Prolonged activation of the endoplasmic reticulum (ER) stress pathway known as the
unfolded protein response (UPR) can lead to cell pathology and subsequent tissue …

Obesity is a major problem worldwide that increases risk for a wide range of diseases,
including diabetes and heart disease. As such, it is increasingly important to understand …

The mammalian circadian clock plays a fundamental role in the liver by regulating fatty acid,
glucose, and xenobiotic metabolism. Impairment of this rhythm has been shown to lead to …

We tested the hypothesis that the pathogenesis of alcoholic liver injury is mediated by
epigenetic changes in regulatory genes that result from the induction of aberrant methionine …

SREBPs (sterol-regulatory-element-binding proteins) are a family of transcription factors that
modulate the expression of several enzymes implicated in endogenous cholesterol, fatty …

Manipulating endoplasmic reticulum stress pathway yields encouraging results for the
treatment of hepatic steatosis in rodents. However, activation of unfolded protein response is …

The signal transduction network in regulating lipid metabolism is a hot topic of biomedical
research. Recent research endeavors reveal that intracellular stress signaling from a cellular …

Evidence suggests a link between Parkinson's disease and the dietary intake of omega (n)−
3 and n− 6 polyunsaturated fatty acids (PUFAs). Presently, we investigated whether an acute …

Little attention has been given to the impact of lipid metabolism on hair follicle biology and
pathology. Three recent papers (one in the current issue) describe a major effect of altered …