Abstract Wessels MW, Willems PJ. Genetic factors in non-syndromic congenital heart
malformations. The genetic defect in most patients with non-syndromic congenital heart …

Congenital heart disease (CHD) is among the most prevalent and fatal of all birth defects.
Deciphering its causes, however, is complicated, as many patients affected by CHD have no …

Background Ostium secundum atrial septal defects (ASDII) account for approximately 10%
of all congenital heart defects (CHD), and mutations in cardiac transcription factors …

GATA6 is a member of the GATA family of transcription factors, and its expression and
functions overlap with those of GATA4 during heart development. Mutations in GATA4 have …

Congenital heart defects (CHDs) are the most common major developmental anomalies and
the most frequent cause for perinatal mortality, but their etiology remains often obscure. We …

Congenital heart disease (CHD) is the most common birth abnormality and the etiology is
unknown in the overwhelming majority of cases. ISLET1 (ISL1) is a transcription factor that …

Background—Variation within a single gene might produce different congenital heart defects
(CHDs) within a family, which could explain the previously reported familial aggregation of …

Congenital heart defects (CHD) are the most common developmental errors in humans,
affecting 8 out of 1,000 newborns. Clinical diagnosis and treatment of CHD has dramatically …

A number of mutations in GATA4 and NKX2. 5 have been identified to be causative for a
subset of familial congenital heart defects (CHDs) and a small number of sporadic CHDs. In …

Familial recurrence of atrial fibrillation (AF) is reported in up to 15% of patients with lone AF.
Recently, it was proposed that congenital defects in the morphogenesis of the pulmonary …