Leptin regulates energy homeostasis and reproductive, neuroendocrine, immune, and
metabolic functions. In this review, we describe the role of leptin in human physiology and …

The world is now experiencing an epidemic of obesity. Although the effects of obesity on the
development of metabolic and cardiovascular problems are well studied, much less is …

The heritability of obesity and body weight in general is high. A small number of confirmed
monogenic forms of obesity—the respective mutations are sufficient by themselves to cause …

The obesity and diabetes pandemics have made it an urgent necessity to define the central
nervous system (CNS) pathways controlling body weight, energy expenditure, and fuel …

The leptin receptor is a single membrane spanning protein which shows structural similarity
to the class 1 cytokine receptor family (22, 23). Several different alternatively spliced …

Objective Obesity is a growing worldwide health problem affecting both adults and children.
Effective prevention and treatment modalities can be achieved by understanding the …

Objective: Leptin, a protein product of adipocytes, plays a critical role in the regulation of
body weight, immune function, pubertal development, and fertility. So far, only three …

To describe our 10-year experience in treating leptin-deficient humans. Three adults and
one boy presented with childhood-onset morbid obesity, hypogonadism and family history of …

Human body weight is maintained at a fairly stable level regardless of changes in energy
intake and energy expenditure. Compensatory mechanisms within the central nervous …

Hypothalamic obesity (HyOb) was first defined as the significant polyphagia and weight gain
that occurs after extensive suprasellar operations for excision of hypothalamic tumours …