Over recent years it has become increasingly clear that innate immune responses can
shape the adaptive immune response. Among the most potent molecules of the innate …

Thymic stromal lymphopoietin (TSLP) is an interleukin 7 (IL-7)-like cytokine originally
characterized by its ability to promote the activation of B cells and dendritic cells (DCs) …

Background Susceptibility to asthma is influenced by genes and environment; implicated
genes may indicate pathways for therapeutic intervention. Genetic risk factors may be useful …

A plethora of epigenetic modifications have been described in the human genome and
shown to play diverse roles in gene regulation, cellular differentiation and the onset of …

Chronic kidney disease (CKD) is a significant public health problem, and recent genetic
studies have identified common CKD susceptibility variants. The CKDGen consortium …

Background Comparison of patients with coronary heart disease and controls in genome-
wide association studies has revealed several single nucleotide polymorphisms (SNPs) …

Eosinophilic esophagitis (EoE) is an allergic disorder characterized by the accumulation of
eosinophils in the esophagus. We report association of EoE with variants at chromosome …

Electrocardiographic measures are indicative of the function of the cardiac conduction
system. To search for sequence variants that modulate heart rate, PR interval and QRS …

Allergic diseases are complex genetic diseases resulting from the effect of multiple genetic
and interacting environmental factors on their pathophysiology. Recent years have seen …

IL-33 is a member of the IL-1 family and mediates its biological effects via the ST2 receptor,
which is selectively expressed on Th2 cells and mast cells. Although polymorphic variation …