The vascular system delivers oxygen and nutrients to every cell in the vertebrate organism.
Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic/ischaemic vascular …

The immunoglobulin superfamily molecule RAGE (receptor for advanced glycation end
product) transduces the effects of multiple ligands, including AGEs (advanced glycation end …

OBJECTIVE Vasculoprotective endothelial progenitor cells (EPCs) are regulated by stromal-
derived factor-1α (SDF-1α) and are reduced in type 2 diabetes. Because SDF-1α is a …

BACKGROUND: Peripheral arterial disease (PAD) is a common cause of disability and
mortality. Up to one third of patients are not susceptible to traditional revascularization and …

Type 2 diabetes is associated with numerous long-term complications. This study aims to
investigate whether impaired function of tissue-resident multipotent cells play role in …

Amputation as a result of impaired wound healing is a serious complication of diabetes.
Inadequate angiogenesis contributes to poor wound healing in diabetic patients. Endothelial …

Rationale: Amniotic membrane is known to have the ability to transdifferentiate into multiple
organs and is expected to stimulate a reduced immunologic reaction. Objective: Determine …

OBJECTIVE Reduction of bone marrow–derived circulating progenitor cells has been
proposed as a novel mechanism of cardiovascular disease in type 2 diabetes. The present …

The discovery of endothelial progenitor cells (EPCs) in human peripheral blood advanced
the field of cell-based therapeutics for many pathological conditions. Despite the lack of …

Percutaneous coronary intervention is associated with mechanical endovascular injury and
endothelial denudation. Re-endothelialization is essential for restoration of normal vascular …