Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disorder characterized by
degeneration of motor neurons and atrophy of skeletal muscle. Mutations in the superoxide …

Disruption of dystrophin or the sarcoglycans within the dystrophin protein complex leads to
muscular dystrophy. The dystrophin complex is enriched in myofibers and concentrated into …

One component of stretch-induced muscle damage is an increase in the permeability of the
cell membrane. As a result soluble myoplasmic proteins leak out of the muscle into the …

Abstract Store-operated Ca 2+ entry (SOCE) contributes to Ca 2+ handling in normal
skeletal muscle function, as well as the progression of muscular dystrophy and sarcopenia …

The sarcoplasmic reticulum (SR) of skeletal muscle contains K+, Cl−, and H+ channels may
facilitate charge neutralization during Ca 2+ release. Our recent studies have identified …

Ca 2+ sparks are short lived and localized Ca 2+ transients resulting from the opening of
ryanodine receptors in sarcoplasmic reticulum. These events relax certain types of smooth …

Calpain activation has been implicated in the disease pathology of Duchenne muscular
dystrophy. Inhibition of calpain has been proposed as a promising therapeutic target, which …

In Duchenne muscular dystrophy, a stop-codon mutation in the dystrophin gene induces an
impairment of skeletal and smooth muscles contraction. In duodenum from mdx mouse, the …

背景: 在骨骼肌胞浆内, Ca 2+ 是神经兴奋和肌肉收缩之间的重要偶联因子,
控制着肌肉收缩的启动和舒张的终止, 对骨骼肌的兴奋收缩偶联起着不可或缺的作用 …

Skeletal muscle is a highly organized tissue that has to be optimized for fast signalling
events conveying electrical excitation to contractile response. The site of electro-chemico …