Antiphospholipid syndrome

G Ruiz-Irastorza, M Crowther, W Branch… - The Lancet, 2010 - thelancet.com
The antiphospholipid syndrome causes venous, arterial, and small-vessel thrombosis;
pregnancy loss; and preterm delivery for patients with severe pre-eclampsia or placental …

The annexin A5-mediated pathogenic mechanism in the antiphospholipid syndrome: role in pregnancy losses and thrombosis

JH Rand, XX Wu, AS Quinn, DJ Taatjes - Lupus, 2010 - journals.sagepub.com
Annexin A5 (AnxA5) binds to phospholipid bilayers, forming two-dimensional crystals that
block the phospholipids from availability for coagulation enzyme reactions. Antiphospholipid …

[HTML][HTML] Clinical course of high‐risk patients diagnosed with antiphospholipid syndrome

V Pengo, A Ruffatti, C Legnani, P Gresele… - Journal of thrombosis …, 2010 - Elsevier
See also Galli M. The antiphospholipid triangle. This issue, pp 234–6. Summary
Background: The characteristics and the clinical course of antiphospholipid syndrome (APS) …

Challenges in the diagnosis of the antiphospholipid syndrome

K Devreese, MF Hoylaerts - Clinical chemistry, 2010 - academic.oup.com
Background: The antiphospholipid syndrome (APS) is an important cause of acquired
thromboembolic complications and pregnancy morbidity. Its diagnosis is based on clinical …

Antiphospholipid-associated thrombocytopenia or autoimmune hemolytic anemia in patients with or without definite primary antiphospholipid syndrome according to …

L Comellas-Kirkerup… - Blood, The Journal …, 2010 - ashpublications.org
The updated Sapporo classification criteria for antiphospholipid syndrome (APS) only
include thrombosis or pregnancy morbidity as clinical criteria. To test this notion, we studied …

[HTML][HTML] IgA anti-β2-glycoprotein I autoantibodies are associated with an increased risk of thromboembolic events in patients with systemic lupus erythematosus

NJ Sweiss, R Bo, R Kapadia, D Manst, F Mahmood… - PLoS …, 2010 - journals.plos.org
Background The clinical utility of testing for antiphospholipid antibodies (aPL) of IgA isotype
remains controversial. Methodology/Principal Findings To address this issue, we reasoned …

[HTML][HTML] Analytical and clinical performance of a new, automated assay panel for the diagnosis of antiphospholipid syndrome

P De Moerloose, G Reber, J Musial, J Arnout - Journal of Thrombosis and …, 2010 - Elsevier
Background: Anticardiolipin (aCL) and anti‐β 2 glycoprotein I (aβ 2 GPI) antibodies are part
of the criteria for antiphospholipid syndrome (APS). Therefore they are widely measured and …

Antiphospholipid syndrome treatment beyond anticoagulation: are we there yet?

SS Pierangeli, D Erkan - Lupus, 2010 - journals.sagepub.com
Persistently positive antiphospholipid antibodies in association with thromboses and/or
pregnancy morbidity is the hallmark of the antiphospholipid syndrome. The management of …

Antiphospholipid antibody profile: implications for the evaluation and management of patients

A Tincani, L Andreoli, C Casu, R Cattaneo, P Meroni - Lupus, 2010 - journals.sagepub.com
According to the classification criteria of antiphospholipid syndrome, lupus anticoagulant,
anticardiolipin and anti-β2 glycoprotein I antibody assays are independent risk factors for the …

Antiphospholipid syndrome: critical analysis of the diagnostic path

V Pengo, A Banzato, E Bison, G Denas… - Lupus, 2010 - journals.sagepub.com
Antiphospholipid syndrome (APS) is diagnosed in the presence of vascular thrombosis or
pregnancy morbidity occurring in patients with circulating antiphospholipid antibodies (lupus …