Cells typically respond quickly to stress, altering their metabolism to compensate. In
mammalian cells, stress signaling usually leads to either cell-cycle arrest or apoptosis …

The Cajal body (CB) is a subnuclear domain that contains proteins and factors involved in a
diverse range of activities including ribonucleoprotein maturation, histone gene transcription …

The abundant heterogeneous nuclear ribonucleoprotein M (hnRNP M) is able to associate
with early spliceosomes and to influence splicing patterns of specific pre-mRNAs. Here, by a …

The Cajal body (CB) is an evolutionarily conserved nuclear subcompartment, enriched in
components of the RNA processing machinery. The composition and dynamics of CBs in …

The breast and ovarian cancer susceptibility gene BRCA1 encodes a tumor suppressor.
BRCA1 protein, which is involved in DNA damage response, has been thought to be found …

Gene-expression strategies are remodeled following exposure to stress. The reactive
oxidants and electrophiles generated after stress actually affects the structural and functional …

Poly (A)-binding proteins (PABPs) are important regulators of mRNA translation and stability.
In mammals four cytoplasmic PABPs with a similar domain structure have been described …

Pre-mRNA splicing is a two-step trans-esterification reaction catalyzed by the spliceosome,
a large complex assembled from pre-formed subcomplexes, called spliceosomal small …

Promyelocytic leukemia nuclear bodies (PML NBs) are dynamic subnuclear protein
compartments that are thought to play roles in many diverse cellular functions. The major …