All living organisms depend on dynamic mechanisms that repeatedly reassess the status of
amassed energy, in order to adapt energy supply to demand. The AMP-activated protein …

AMP-activated protein kinase (AMPK) is a cellular energy sensor activated by metabolic
stresses that either inhibit ATP synthesis or accelerate ATP consumption. Activation of AMPK …

Metformin is widely used to treat hyperglycemia in individuals with type 2 diabetes. Recently
the LKB1/AMP-activated protein kinase (LKB1/AMPK) pathway was proposed to mediate the …

Drug discovery and chemical genetic efforts typically focus on the identification and design
of inhibitors or loss-of-function probes as a means to perturb enzyme function. These tools …

Long Term Potentiation (LTP) is a leading candidate mechanism for learning and memory
and is also thought to play a role in the progression of seizures to intractable epilepsy …

Activation of AMPK (AMP-activated protein kinase) by phosphorylation at Thr172 is
catalysed by at least two distinct upstream kinases, ie the tumour suppressor LKB1, and …

Hepatitis C virus (HCV) infection is associated with dysregulation of both lipid and glucose
metabolism. As well as contributing to viral replication, these perturbations influence the …

Resveratrol functions as an agonist for estrogen receptor (ER)-mediated transcription.
However, other researchers have reported that resveratrol decreases proliferation of breast …

Abstract Adenosine Monophosphate-activated Protein Kinase (AMPK), a serine/threonine
kinase and a member of the Snf1/AMPK protein kinase family, consists of three protein …

Skeletal muscle phenotype plays a critical role in human performance and health, and
skeletal muscle oxidative capacity is a key determinant of exercise tolerance. More recently …