Some cancer types are strongly associated with chronic inflammatory or infectious diseases
whereas others are not, but an inflammatory component is present in most human neoplastic …

Papillary thyroid cancer (PTC) is a common endocrine malignancy that frequently harbors
the oncogenic T1799A BRAF mutation. As a novel prognostic molecular marker, this …

Background Chemotherapy has historically proven ineffective in advanced differentiated
thyroid cancers, but the realisation that various tyrosine kinases are activated in the disease …

In different human carcinoma types, mast cell infiltrate increases with respect to normal
tissue and mast cell density correlates with a bad prognosis. To assess the role of mast cells …

Objectives: Until recently, treatment options for patients with progressive, radioactive iodine-
resistant differentiated thyroid cancer (DTC) have been limited. In our clinical practice, we …

Papillary thyroid cancer (PTC) is the most common endocrine malignancy, accounting for 85–
90% of all thyroid cancers. Genetic alternations involving the mitogen-activated protein …

Gene expression profiling shows that, by gene signature, the difference between BRAF-
positive and BRAF-negative PTC is so distinct that BRAF-positive cancer may be regarded …

The precise diagnosis of thyroid neoplasias will guide surgical management. Primary thyroid
paraganglioma has been rarely reported. Data on prevalence, immunohistochemistry (IHC) …

Systemic chemotherapies for advanced or metastatic thyroid carcinomas have been of only
limited effectiveness. For patients with differentiated or medullary carcinomas unresponsive …

Hypoxia-inducible factor-1α is found frequently overexpressed in solid tumors cells, exerting
an important role in angiogenesis, glucose metabolism, cell proliferation, survival and …