Hirschsprung's disease (HSCR) is characterized by absence of the enteric nervous system
in a variable portion of the distal gut. Affected infants usually present in the days after birth …

Mammary stem cells (MaSCs) play critical roles in normal development and perhaps
tumorigenesis of the mammary gland. Using combined cell markers, adult MaSCs have …

Ret signaling is critical for formation of the enteric nervous system (ENS) because Ret
activation promotes ENS precursor survival, proliferation, and migration and provides trophic …

Aims Infantile haemangioma is a tumour of the microvasculature characterised by
aggressive angiogenesis during infancy and spontaneously gradual involution, often …

Context: The RET receptor tyrosine kinase is an important mediator of several human
diseases, most notably of neuroendocrine cancers. These diseases are characterized by …

The mechanisms that regulate peripheral nervous system (PNS) gliogenesis are
incompletely understood. For example, gut neural crest stem cells (NCSCs) do not respond …

Context: Medullary thyroid carcinoma (MTC) is a cancer of the parafollicular C cells
commonly caused by an inherited or acquired RET proto-oncogene mutation. Therapeutic …

Background Most enteric neurones arise from neural crest cells that originate in the post‐otic
hindbrain, and migrate into and along the developing gastrointestinal tract. There is currently …

Abnormalities in the development of enteric neural crest-derived progenitors (ENPs) that
generate the enteric nervous system (ENS) can lead to aganglionosis in a variable portion of …

The enteric nervous system is derived from neural crest cells that emigrate from the
hindbrain, enter the foregut and colonise the entire length of the gastrointestinal tract …