Interleukin‐17 and its target genes: mechanisms of interleukin‐17 function in disease

RM Onishi, SL Gaffen - Immunology, 2010 - Wiley Online Library
Summary Interleukin‐17 (IL‐17) has emerged as a central player in the mammalian immune
system. Although this cytokine exerts a host‐defensive role in many infectious diseases, it …

Destructive and protective roles of cytokines in periodontitis: a re-appraisal from host defense and tissue destruction viewpoints

GP Garlet - Journal of dental research, 2010 - journals.sagepub.com
Periodontal diseases (PD) are chronic infectious inflammatory diseases characterized by the
destruction of tooth-supporting structures, being the presence of periodontopathogens …

Cytokine responses against periodontal infection: protective and destructive roles.

YCG Liu, UH Lerner, YTA Teng - Periodontology 2000, 2010 - search.ebscohost.com
The article discusses the protective and destructive roles of cytokine responses against
periodontal infections. It stresses the activities and functions of the protein molecule …

Immunomodulatory properties of stem cells from human exfoliated deciduous teeth

T Yamaza, A Kentaro, C Chen, Y Liu, Y Shi… - Stem cell research & …, 2010 - Springer
Introduction Stem cells from human exfoliated deciduous teeth (SHED) have been identified
as a population of postnatal stem cells capable of differentiating into osteogenic and …

Interleukin-17A upregulates receptor activator of NF-κB on osteoclast precursors

IE Adamopoulos, C Chao, R Geissler, D Laface… - Arthritis research & …, 2010 - Springer
Introduction The interaction between the immune and skeletal systems is evidenced by the
bone loss observed in autoimmune diseases such as rheumatoid arthritis. In this paper we …

A novel role of IL-17–producing lymphocytes in mediating lytic bone disease in multiple myeloma

K Noonan, L Marchionni, J Anderson… - Blood, The Journal …, 2010 - ashpublications.org
Osteoclast (OC)–mediated lytic bone disease remains a cause of major morbidity in multiple
myeloma. Here we demonstrate the critical role of interleukin-17–producing marrow …

Regulatory T cells protect from local and systemic bone destruction in arthritis

MM Zaiss, B Frey, A Hess, J Zwerina… - The Journal of …, 2010 - journals.aai.org
We previously demonstrated the suppressive effects of regulatory T cells (Treg cells) on
osteoclast differentiation in vitro. In this article, we show that blood markers of bone …

Natural killer cells trigger osteoclastogenesis and bone destruction in arthritis

K Söderström, E Stein, P Colmenero… - Proceedings of the …, 2010 - National Acad Sciences
Osteoclasts are bone-eroding cells that develop from monocytic precursor cells in the
presence of receptor activator of NF-κB ligand (RANKL) and macrophage colony-stimulating …

Regulatory T cells attenuate experimental periodontitis progression in mice

GP Garlet, CR Cardoso, FS Mariano… - Journal of clinical …, 2010 - Wiley Online Library
Garlet GP, Cardoso CR, Mariano FS, Claudino M, de Assis GF, Campanelli AP, Ávila‐
Campos MJ, Silva JS. Regulatory T cells attenuate experimental periodontitis progression in …

Modulation of experimental autoimmune encephalomyelitis through TRAF3-mediated suppression of interleukin 17 receptor signaling

S Zhu, W Pan, P Shi, H Gao, F Zhao, X Song… - Journal of Experimental …, 2010 - rupress.org
Interleukin 17 (IL-17) plays critical roles in the pathogenesis of various autoimmune
diseases, including experimental autoimmune encephalomyelitis (EAE). How the signals …