Cocaine‐induced neuroadaptations in glutamate transmission: potential therapeutic targets for craving and addiction
HD Schmidt, RC Pierce - Annals of the New York Academy of …, 2010 - Wiley Online Library
A growing body of evidence indicates that repeated exposure to cocaine leads to profound
changes in glutamate transmission in limbic nuclei, particularly the nucleus accumbens. This …
changes in glutamate transmission in limbic nuclei, particularly the nucleus accumbens. This …
Chronic cocaine-induced H3 acetylation and transcriptional activation of CaMKIIα in the nucleus accumbens is critical for motivation for drug reinforcement
L Wang, Z Lv, Z Hu, J Sheng, B Hui, J Sun… - …, 2010 - nature.com
The regulation of gene expression in the brain reward regions is known to contribute to the
pathogenesis and persistence of drug addiction. Increasing evidence suggests that the …
pathogenesis and persistence of drug addiction. Increasing evidence suggests that the …
Gene expression changes in the medial prefrontal cortex and nucleus accumbens following abstinence from cocaine self-administration
WM Freeman, ME Lull, KM Patel, RM Brucklacher… - BMC neuroscience, 2010 - Springer
Background Many studies of cocaine-responsive gene expression have focused on
changes occurring during cocaine exposure, but few studies have examined the persistence …
changes occurring during cocaine exposure, but few studies have examined the persistence …
Cocainomics: new insights into the molecular basis of cocaine addiction
SE Hemby - Journal of Neuroimmune Pharmacology, 2010 - Springer
Until recently, knowledge of the impact of abused drugs on gene and protein expression in
the brain was limited to less than 100 targets. With the advent of high-throughput genomic …
the brain was limited to less than 100 targets. With the advent of high-throughput genomic …
Clinical application for the preservation of phospho-proteins through in-situ tissue stabilization
CB Rountree, CA Van Kirk, H You, W Ding, H Dang… - Proteome science, 2010 - Springer
Background Protein biomarkers will play a pivotal role in the future of personalized medicine
for both diagnosis and treatment decision-making. While the results of several pre-clinical …
for both diagnosis and treatment decision-making. While the results of several pre-clinical …
Arginine vasopressin gene expression changes within the nucleus accumbens during environment elicited cocaine-conditioned response in rats
E Rodríguez-Borrero, F Rivera-Escalera, F Candelas… - …, 2010 - Elsevier
It is known that changes in gene expression within the nucleus accumbens (NAc) occur
during cocaine dependence development. However, identification of specific genes involved …
during cocaine dependence development. However, identification of specific genes involved …