The widespread increase in life expectancy is accompanied by an increased prevalence of
features of physical frailty. Signs and symptoms may include sarcopenia and osteopenia …

Myostatin is a member of the transforming growth factor β superfamily of secreted growth
factors that negatively regulates skeletal muscle size. Mice null for the myostatin gene have …

Myostatin (MSTN) is a transforming growth factor-β family member that plays a critical role in
regulating skeletal muscle mass. Genetic studies in multiple species have demonstrated that …

Duchenne muscular dystrophy is characterized by muscular atrophy, fibrosis, and fat
accumulation. Several groups have demonstrated that in the mdx mouse, the exon-skipping …

Duchenne muscular dystrophy (DMD) is characterized by progressive skeletal muscle
wasting and weakness, leading to premature death from respiratory and/or cardiac failure. A …

Modulation of transforming growth factor‐β (TGF‐β) signaling to promote muscle growth
holds tremendous promise for the muscular dystrophies and other disorders involving the …

Myostatin is well established as a negative regulator of skeletal muscle growth, but its role in
the heart is controversial. Our goal in this study was to characterize myostatin regulation …

Myostatin is a member of the transforming growth factor beta (TGF‐β) superfamily that
functions as a negative regulator of skeletal muscle development and growth. Myostatin …

Myostatin is well established as a negative regulator of skeletal muscle growth, but its role in
the heart is controversial. Our goal in this study was to characterize myostatin regulation …

Little is known of the mechanisms regulating the growth and development of muscle tissue
in teleost fish. Mammalian muscle growth is negatively regulated by multiple signaling …