Extensive research during the past 2 decades has revealed the mechanism by which
continued oxidative stress can lead to chronic inflammation, which in turn could mediate …

Plasticity is a hallmark of cells of the myelomonocytic lineage. In response to innate
recognition or signals from lymphocyte subsets, mononuclear phagocytes undergo adaptive …

Nearly a century after the significance of the human complement system was recognized, we
have come to realize that its functions extend far beyond the elimination of microbes …

The concept of an alternative pathway of macrophage activation has stimulated interest in its
definition, mechanism, and functional significance in homeostasis and disease. We assess …

There is persuasive clinical and experimental evidence that macrophages promote cancer
initiation and malignant progression. During tumor initiation, they create an inflammatory …

Inflammatory responses play decisive roles at different stages of tumor development,
including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation …

Nonresolving inflammation is a major driver of disease. Perpetuation of inflammation is an
inherent risk because inflammation can damage tissue and necrosis can provoke …

The connection between inflammation and tumorigenesis is well-established and in the last
decade has received a great deal of supporting evidence from genetic, pharmacological …

The existence of circulating microRNAs (miRNAs) in the blood of cancer patients has raised
the possibility that miRNAs may serve as a novel diagnostic marker. However, the secretory …

Solid tumors are not simply clones of cancer cells. Instead, they are abnormal organs
composed of multiple cell types and extracellular matrix. Some aspects of tumor …