Enzymatic crosslinking of dextran-tyramine (Dex-TA) conjugates in the presence of
horseradish peroxidase and hydrogen peroxide was successively applied in the preparation …

Objective Nitric oxide is an important mediator in Osteoarthritis (OA), and causes apoptosis
and dedifferentiation in articular chondrocytes. Protein kinase Cα is involved in modulating …

Endoplasmic reticulum (ER) stress regulates a wide range of cellular responses including
apoptosis, proliferation, inflammation, and differentiation in mammalian cells. In this study …

This study aimed to investigate the chondrogenic transdifferentiation potential of human
dermal fibroblasts (DFs) by stimulation with cartilage-derived morphogenetic protein 1 …

Exposure to dioxin-like compounds is associated with arthritis in humans. A recent study
reported that 2, 3, 7, 8,-tetrachlorodibenzo-p-dioxin (TCDD) induces apoptosis in …

deoxy-D-glucose (2DG) is known as a synthetic inhibitor of glucose. 2DG regulates various
cellular responses including proliferation, apoptosis and differentiation by regulation of …

Positive associations of halogenated aromatic hydrocarbons and arthritis have been
reported in human populations. Although 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD), the …

The Notch family is involved in cell differentiation during embryogenesis. Osteoarthritic
chondrocytes undergo morphological and biochemical changes leading to the de …

The human body is composed of 60 trillion cells, which have their origin in a fertilized egg.
During development, the potential of a cell or tissue can be achieved by environmental …

A multitude of signalling cascades are implicated in the homeostasis of articular
chondrocytes. However, the identity of these signalling pathways is not fully established. The …