Mesenchymal stem cells as therapeutics

B Parekkadan, JM Milwid - Annual review of biomedical …, 2010 - annualreviews.org
Mesenchymal stem cells (MSCs) are multipotent cells that are being clinically explored as a
new therapeutic for treating a variety of immune-mediated diseases. First heralded as a …

Cell sheet engineering: a unique nanotechnology for scaffold‐free tissue reconstruction with clinical applications in regenerative medicine

I Elloumi‐Hannachi, M Yamato… - Journal of internal …, 2010 - Wiley Online Library
Cell sheet technology (CST) is based on the use of thermoresponsive polymers, poly (N‐
isopropylacrylamide)(PIPAAm). The surface of PIPAAms is formulated in such a way as to …

[HTML][HTML] Mesenchymal stem cells: Molecular characteristics and clinical applications

F Rastegar, D Shenaq, J Huang, W Zhang… - World journal of stem …, 2010 - ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) are non-hematopoietic stem cells with the capacity to
differentiate into tissues of both mesenchymal and non-mesenchymal origin. MSCs can …

Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells

JM Gimble, F Guilak, BA Bunnell - Stem cell research & therapy, 2010 - Springer
Adipose tissue is now recognized as an accessible, abundant, and reliable site for the
isolation of adult stem cells suitable for tissue engineering and regenerative medicine …

Mesenchymal stem cells for acute lung injury: preclinical evidence

MA Matthay, A Goolaerts, JP Howard… - Critical care …, 2010 - journals.lww.com
Several experimental studies have suggested that mesenchymal stem cells may have value
for the treatment of clinical disorders, including myocardial infarction, diabetes, acute renal …

Cellular cardiomyoplasty and cardiac tissue engineering for myocardial therapy

F Wang, J Guan - Advanced drug delivery reviews, 2010 - Elsevier
Heart diseases, including myocardial infarction (MI) and congestive heart failure (CHF),
have high mortality rates. Both MI and CHF are characterized by cardiac muscle damage …

Secretory profiles and wound healing effects of human amniotic fluid–derived mesenchymal stem cells

BS Yoon, JH Moon, EK Jun, J Kim, I Maeng… - Stem cells and …, 2010 - liebertpub.com
Recent evidence shows that amniotic fluid (AF) contains multiple cell types derived from the
developing fetus, and may represent a novel source of stem cells for cell therapy. In this …

Therapeutic potential of adipose-derived stem cells in vascular growth and tissue repair

SJ Hong, DO Traktuev, KL March - Current opinion in organ …, 2010 - journals.lww.com
ASCs may ultimately represent a valuable therapeutic option in tissue rescue and repair
based on their ready availability, proangiogenesis and antiapoptotic factor secretion …

Cell therapy of congenital corneal diseases with umbilical mesenchymal stem cells: lumican null mice

H Liu, J Zhang, CY Liu, IJ Wang, M Sieber, J Chang… - PloS one, 2010 - journals.plos.org
Background Keratoplasty is the most effective treatment for corneal blindness, but
suboptimal medical conditions and lack of qualified medical personnel and donated cornea …

Apoptosis of mesenchymal stem cells induced by hydrogen peroxide concerns both endoplasmic reticulum stress and mitochondrial death pathway through regulation …

H Wei, Z Li, S Hu, X Chen… - Journal of cellular …, 2010 - Wiley Online Library
Poor survival of mesenchymal stem cells (MSCs) compromised the efficacy of stem cell
therapy for myocardial infarction. The increase of exogenous reactive oxygen species (ROS) …