Small molecule inhibitors that selectively target cancer cells and not normal cells would be
valuable anti-cancer therapeutics. The mammalian target of rapamycin complex 2 …

Cells of all living organisms contain complex signal transduction networks to ensure that a
wide range of physiological properties are properly adapted to the environmental conditions …

Phospholipid-binding modules such as PH, C1, and C2 domains play crucial roles in
location-dependent regulation of many protein kinases. Here, we identify the KA1 domain …

S tudies using Saccharomyces cerevisiae, the common baker's or brewer's yeast, have
progressed over the past twenty years from knowing which sphingolipids are present in cells …

The protein kinase C (PKC)-MAPK signaling cascade is activated and is essential for
viability when cells are starved for the phospholipid precursor inositol. In this study, we …

Calcineurin is a calcium-activated phosphatase that controls morphogenesis and stress
responses in eukaryotes. Fungal pathogens have adopted the calcineurin pathway to …

Myosins‐I are conserved proteins that bear an N‐terminal motor head followed by a Tail
Homology 1 (TH1) lipid‐binding domain. Some myosins‐I have an additional C‐terminal …

I. Abstract Studies in budding yeast, Saccharomyces cerevisiae, have established an
important role for the target of rapamycin (TOR) signaling network in regulating cell growth …

Sphingolipid metabolism in trans-golgi/endosomal membranes and the regulation of intracellular
homeostatic processes in eukaryotic cells - ScienceDirect Skip to main contentSkip to article …

Pdr5 and Yor1 are two ATP-binding cassette transporters regulated by the pleiotropic drug
resistance (PDR) network in the yeast Saccharomyces cerevisiae. Recent work …