The return of a forgotten polymer—Polycaprolactone in the 21st century

MA Woodruff, DW Hutmacher - Progress in polymer science, 2010 - Elsevier
During the resorbable-polymer-boom of the 1970s and 1980s, polycaprolactone (PCL) was
used extensively in the biomaterials field and a number of drug-delivery devices. Its …

Poly (lactic acid) modifications

RM Rasal, AV Janorkar, DE Hirt - Progress in polymer science, 2010 - Elsevier
Poly (lactic acid) or polylactide (PLA) is the most extensively researched and utilized
biodegradable and renewable thermoplastic polyester, with potential to replace …

Biomaterials/tissue interactions: possible solutions to overcome foreign body response

JM Morais, F Papadimitrakopoulos, DJ Burgess - The AAPS journal, 2010 - Springer
In recent years, a variety of biomaterial implantable devices has been developed. Of
particular significance to pharmaceutical sciences is the progress made on the development …

Bone grafting, orthopaedic biomaterials, and the clinical need for bone engineering

AS Brydone, D Meek… - Proceedings of the …, 2010 - journals.sagepub.com
As the population ages, the number of operations performed on bone is expected to
increase. Diseases such as arthritis, tumours, and trauma can lead to defects in the skeleton …

Polylactic acid (PLA): research, development and industrialization

X Pang, X Zhuang, Z Tang, X Chen - Biotechnology journal, 2010 - Wiley Online Library
Polylactide (PLA) is a biodegradable, aliphatic polyester derived from lactic acid. It has
similar mechanical properties to polyethylene terephthalate, but has a significantly lower …

Issues in long-term protein delivery using biodegradable microparticles

M Ye, S Kim, K Park - Journal of Controlled Release, 2010 - Elsevier
Recently, a variety of bioactive protein drugs have been available in large quantities as a
result of advances in biotechnology. Such availability has prompted development of long …

Iodinated blood pool contrast media for preclinical X-ray imaging applications–a review

F Hallouard, N Anton, P Choquet, A Constantinesco… - Biomaterials, 2010 - Elsevier
The in vivo X-ray micro-computed tomography (micro-CT) is a very powerful and non-
invasive tool used to establish high-resolution images with isotropic voxels in typical scan …

Polymeric drug delivery systems for localized cancer chemotherapy

R De Souza, P Zahedi, CJ Allen, M Piquette-Miller - Drug delivery, 2010 - Taylor & Francis
Cancer has become one of the most difficult health challenges of our time, accounting for
millions of deaths yearly. Systemic chemotherapy is the most common therapeutic approach; …

Intrathecal delivery of a polymeric nanocomposite hydrogel after spinal cord injury

MD Baumann, CE Kang, CH Tator, MS Shoichet - Biomaterials, 2010 - Elsevier
Major traumatic spinal cord injury (SCI) results in permanent paralysis below the site of
injury. The effectiveness of systemically delivered pharmacological therapies against SCI …

In vitro degradation and cell attachment of a PLGA coated biodegradable Mg–6Zn based alloy

JN Li, P Cao, XN Zhang, SX Zhang, YH He - Journal of materials science, 2010 - Springer
Currently available engineering magnesium alloys have several critical concerns if they are
about to be used as biomaterials, particularly the concern about the toxicity of the common …