When the food intake of organisms such as yeast and rodents is reduced (dietary restriction),
they live longer than organisms fed a normal diet. A similar effect is seen when the activity of …

Many of the most dangerous human diseases are transmitted by insect vectors. After
decades of repeated insecticide use, all of these vector species have demonstrated the …

Multicellular animals match costly activities, such as growth and reproduction, to the
environment through nutrient-sensing pathways. The insulin/IGF signaling (IIS) pathway …

The free radical theory of aging proposes a causal relationship between reactive oxygen
species (ROS) and aging. While it is clear that oxidative damage increases with age, its role …

Human life expectancy in developed countries has increased steadily for over 150 years,
through improvements in public health and lifestyle. More people are hence living long …

Insulin/IGF‐1 signaling controls metabolism, stress resistance and aging in Caenorhabditis
elegans by regulating the activity of the DAF‐16/FoxO transcription factor (TF). However, the …

Dietary restriction (DR) and reduced growth factor signaling both elevate resistance to
oxidative stress, reduce macromolecular damage, and increase lifespan in model …

FOXO transcription factors are an important, conserved family of regulators of cellular
processes including metabolism, cell-cycle progression, apoptosis and stress resistance …

Background Ageing, immunity and stresstolerance are inherent characteristics of all
organisms. In animals, these traits are regulated, at least in part, by forkhead transcription …

Новые молекулярно-генетические методы существенно расширили возможности
быстрого и эффективного исследования генома человека и открыли новые подходы …