Inflammation and oxidative stress contribute to the pathology of many diseases, but specific
therapeutic targets remain elusive. Oxidative stress, generated by excessive reactive oxygen …

Tissue homeostasis in metazoa requires the rapid and efficient clearance of dying cells by
professional or semi-professional phagocytes. Impairment of this finely regulated …

Tumor drug resistance significantly limits the success of chemotherapy in the clinic. Tumor
cells utilize multiple mechanisms to prevent the accumulation of anticancer drugs at their …

Ag cross presentation is an important mechanism for CD8+ T cell activation by APCs. We
have investigated mechanisms involved in heat shock protein 90 (Hsp90) chaperone …

Neurologic disease promoted by microbial pathogens, sterile injury, or neurodegeneration
rapidly induces innate immunity in adjacent healthy tissue, which in turn contributes …

In recent years, it has been hypothesised that a new signalling system may exist in
vertebrates in which secreted molecular chaperones form a dynamic continuum between the …

Recent evidence in humans indicate that defective phagocytic clearance of dying cells is
linked to progression of advanced atherosclerotic lesions, the precursor to …

C1qmediated removal of immune complexes and apoptotic cells plays an important role in
tissue homeostasis and the prevention of autoimmune conditions. It has been suggested …

Our previous studies have demonstrated that the natural chaperone complexes of full-length
tumor protein Ags (eg, gp100) and large stress proteins (eg, hsp110 and grp170) with …

Exogenous antigens enter antigen-presenting cells through non-specific mechanisms and
are presented by the MHC II molecules. We show here that antigens chaperoned by the heat …