Emerging roles of Wnts in the adult nervous system
NC Inestrosa, E Arenas - Nature Reviews Neuroscience, 2010 - nature.com
The roles of the Wnt signalling pathway in several developmental processes, including
synaptic differentiation, are well characterized. The expression of Wnt ligands and Wnt …
synaptic differentiation, are well characterized. The expression of Wnt ligands and Wnt …
c-Jun N-terminal kinase (JNK) signaling: recent advances and challenges
MA Bogoyevitch, KRW Ngoei, TT Zhao… - … et Biophysica Acta (BBA …, 2010 - Elsevier
c-Jun N-terminal kinases (JNKs), first characterized as stress-activated members of the
mitogen-activated protein kinase (MAPK) family, have become a focus of inhibitor screening …
mitogen-activated protein kinase (MAPK) family, have become a focus of inhibitor screening …
Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1ΔE9 mouse model …
EM Toledo, NC Inestrosa - Molecular psychiatry, 2010 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive
deterioration of cognitive abilities, accumulation of the amyloid-β-peptide (Aβ) and synaptic …
deterioration of cognitive abilities, accumulation of the amyloid-β-peptide (Aβ) and synaptic …
Guidance molecules in synapse formation and plasticity
A major goal of modern neuroscience research is to understand the cellular and molecular
processes that control the formation, function, and remodeling of chemical synapses. In this …
processes that control the formation, function, and remodeling of chemical synapses. In this …
Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses
Growing evidence indicates that Wingless-type (Wnt) signaling plays an important role in the
maturation of the central nervous system. We report here that Wingless-type family member …
maturation of the central nervous system. We report here that Wingless-type family member …
Wnt-5a modulates recycling of functional GABAA receptors on hippocampal neurons
GABAA receptors (GABAA-Rs) play a significant role in mediating fast synaptic inhibition
and it is the main inhibitory receptor in the CNS. The role of Wnt signaling in coordinating …
and it is the main inhibitory receptor in the CNS. The role of Wnt signaling in coordinating …
Wnt-5aoccludes Aβ oligomer-induced depression of glutamatergic transmission in hippocampal neurons
Background Soluble amyloid-β (Aβ;) oligomers have been recognized to be early and key
intermediates in Alzheimer's disease (AD)-related synaptic dysfunction. Aβ oligomers block …
intermediates in Alzheimer's disease (AD)-related synaptic dysfunction. Aβ oligomers block …
Amyloid-β-Acetylcholinesterase complexes potentiate neurodegenerative changes induced by the Aβ peptide. Implications for the pathogenesis of Alzheimer's …
MC Dinamarca, JP Sagal, RA Quintanilla… - Molecular …, 2010 - Springer
The presence of amyloid-β (Aβ) deposits in selected brain regions is a hallmark of
Alzheimer's disease (AD). The amyloid deposits have" chaperone molecules" which play …
Alzheimer's disease (AD). The amyloid deposits have" chaperone molecules" which play …
WNT5A antagonizes WNT/β-catenin signaling and is frequently silenced by promoter CpG methylation in esophageal squamous cell carcinoma
WNT5A is classified as a non-transforming WNT family member whose role in
carcinogenesis is still ambiguous. It exhibits tumor suppressor activities in some cancers …
carcinogenesis is still ambiguous. It exhibits tumor suppressor activities in some cancers …
A postsynaptic signaling pathway that may account for the cognitive defect due to IL1RAPL1 mutation
Background Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) gene mutations are
associated with cognitive impairment ranging from nonsyndromic X-linked mental …
associated with cognitive impairment ranging from nonsyndromic X-linked mental …