ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
High-throughput sequencing platforms are generating massive amounts of genetic variation
data for diverse genomes, but it remains a challenge to pinpoint a small subset of …
data for diverse genomes, but it remains a challenge to pinpoint a small subset of …
Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS
Although genome-wide association studies (GWAS) of complex traits have yielded more
reproducible associations than had been discovered using any other approach, the loci …
reproducible associations than had been discovered using any other approach, the loci …
[HTML][HTML] Emerging role of microRNAs in drug response
Current pharmacogenomic studies have begun to integrate genetics, gene expression and
pharmacologic phenotypes. MicroRNAs (miRNAs), small RNAs (21–25 nucleotides) found …
pharmacologic phenotypes. MicroRNAs (miRNAs), small RNAs (21–25 nucleotides) found …
Impact of the 1000 genomes project on the next wave of pharmacogenomic discovery
The 1000 Genomes Project aims to provide detailed genetic variation data on over 1000
genomes from worldwide populations using the next-generation sequencing technologies …
genomes from worldwide populations using the next-generation sequencing technologies …
Chemotherapeutic drug susceptibility associated SNPs are enriched in expression quantitative trait loci
Pharmacogenomics has employed candidate gene studies and, more recently, genome-
wide association studies (GWAS) in efforts to identify loci associated with drug response …
wide association studies (GWAS) in efforts to identify loci associated with drug response …
Exprtarget: an integrative approach to predicting human microRNA targets
Variation in gene expression has been observed in natural populations and associated with
complex traits or phenotypes such as disease susceptibility and drug response. Gene …
complex traits or phenotypes such as disease susceptibility and drug response. Gene …
PACdb: a database for cell-based pharmacogenomics
Abstract We have developed Pharmacogenomics And Cell database (PACdb), a results
database that makes available relationships between single nucleotide polymorphisms …
database that makes available relationships between single nucleotide polymorphisms …
Multigenic modeling of complex disease by random forests
YV Sun - Advances in genetics, 2010 - Elsevier
The genetics and heredity of complex human traits have been studied for over a century.
Many genes have been implicated in these complex traits. Genome-wide association …
Many genes have been implicated in these complex traits. Genome-wide association …
SeqAnt: a web service to rapidly identify and annotate DNA sequence variations
Background The enormous throughput and low cost of second-generation sequencing
platforms now allow research and clinical geneticists to routinely perform single experiments …
platforms now allow research and clinical geneticists to routinely perform single experiments …
Promoter Variant of PIK3C3 Is Associated with Autoimmunity against Ro and Sm Epitopes in African‐American Lupus Patients
SN Kariuki, BS Franek, RA Mikolaitis… - BioMed Research …, 2010 - Wiley Online Library
The PIK3C3 locus was implicated in case‐case genome‐wide association study of systemic
lupus erythematosus (SLE) which we had performed to detect genes associated with …
lupus erythematosus (SLE) which we had performed to detect genes associated with …