Regulation of the HIF-1α level is essential for hematopoietic stem cells
Hematopoietic stem cells (HSCs) are sustained in a specific microenvironment known as the
stem cell niche. Mammalian HSCs are kept quiescent in the endosteal niche, a hypoxic zone …
stem cell niche. Mammalian HSCs are kept quiescent in the endosteal niche, a hypoxic zone …
[HTML][HTML] NF-κB mediates aberrant activation of HIF-1 in malignant lymphoma
Q Qiao, Y Nozaki, K Sakoe, N Komatsu, K Kirito - Experimental hematology, 2010 - Elsevier
OBJECTIVE: The goal of this study was to explore the molecular mechanisms of aberrant
hypoxia inducible factor-1 (HIF− 1) activation in lymphoma cells. MATERIALS AND …
hypoxia inducible factor-1 (HIF− 1) activation in lymphoma cells. MATERIALS AND …
Granulocyte colony-stimulating factor activating HIF-1α acts synergistically with erythropoietin to promote tissue plasticity
Stroke and peripheral limb ischemia are serious clinical problems with poor prognosis and
limited treatment. The cytokines erythropoietin (EPO) and granulocyte-colony stimulating …
limited treatment. The cytokines erythropoietin (EPO) and granulocyte-colony stimulating …
Adventures in time and space: Nonlinearity and complexity of cytokine effects on stem cell fate decisions
J Audet - Biotechnology and bioengineering, 2010 - Wiley Online Library
Cytokines are central factors in the control of stem cell fate decisions and, as such, they are
invaluable to those interested in the manipulation of stem and progenitor cells for clinical or …
invaluable to those interested in the manipulation of stem and progenitor cells for clinical or …
[PDF][PDF] Mpl receptor defect leads to earlier appearance of hematopoietic cells/hematopoietic stem cells in the Aorta-Gonad-Mesonephros region, with increased …
M Fleury, L Petit-Cocault, D Clay… - The International Journal …, 2010 - researchgate.net
In a previous study, we underlined the functional role of the TPO receptor, Mpl, in the
establishment of definitive mouse hematopoiesis, by demonstrating that the lack of Mpl led …
establishment of definitive mouse hematopoiesis, by demonstrating that the lack of Mpl led …
Responses to Tumour initiating factors and Regulation of Normal and Malignant Haematopoiesis
E Diffner - 2010 - portal.research.lu.se
The haematopoietic stem cell (HSC) resides within a specific environment enabling it to
retain its self-renewal capacity or quiescent state. It is proposed that the HSC niche is …
retain its self-renewal capacity or quiescent state. It is proposed that the HSC niche is …
[PDF][PDF] Granulocyte Colony-Stimulating Factor Activating HIF-1a Acts Synergistically with
SP Liu, SD Lee, HT Lee, DD Liu, HJ Wang - 2010 - academia.edu
Stroke and peripheral limb ischemia are serious clinical problems with poor prognosis and
limited treatment. The cytokines erythropoietin (EPO) and granulocyte-colony stimulating …
limited treatment. The cytokines erythropoietin (EPO) and granulocyte-colony stimulating …