BACKGROUND: Peripheral arterial disease (PAD) is a common cause of disability and
mortality. Up to one third of patients are not susceptible to traditional revascularization and …

Atherosclerotic peripheral artery disease (PAD) is a common manifestation of
atherosclerosis. The occlusion of large limb arteries leads to ischaemia with claudication …

OBJECTIVE Vasculoprotective endothelial progenitor cells (EPCs) are regulated by stromal-
derived factor-1α (SDF-1α) and are reduced in type 2 diabetes. Because SDF-1α is a …

OBJECTIVE Reduction of bone marrow–derived circulating progenitor cells has been
proposed as a novel mechanism of cardiovascular disease in type 2 diabetes. The present …

The discovery of endothelial progenitor cells (EPCs) in human peripheral blood advanced
the field of cell-based therapeutics for many pathological conditions. Despite the lack of …

Transplantation of human cord blood-derived endothelial progenitor cells (EPCs) is reported
to contribute to neovascularization in various ischemic diseases. However, the possible …

OBJECTIVE: Metabolic syndrome (MetS) is characterized by low-grade inflammation and
confers an increased risk for cardiovascular disease. Endothelial progenitor cells (EPCs) are …

Patients suffering from both diabetes and PAD (peripheral arterial disease) are at risk of
developing critical limb ischaemia and ulceration, and potentially requiring limb amputation …

OBJECTIVE Progenitor cells (PCs) contribute to postnatal neovascularization and tissue
repair. Here, we explore the mechanism contributing to decreased diabetic circulating PC …

Diabetes mellitus increases cardiovascular risk through its negative impact on vascular
endothelium. Although glucotoxicity and lipotoxicity account for endothelial cell damage …