Increasing life expectancy in developed countries has led to a growing prevalence of
arthritic disorders, which has been accompanied by increasing prescriptions for nonsteroidal …

Nonsteroidal antinflammatory drugs (NSAIDs) inhibit prostaglandin formation by
cyclooxygenases (COX) 1 and 2. NSAIDs selective for inhibition of COX-2 are less likely …

Background and purpose: Hydrogen sulphide is an important mediator of gastric mucosal
defence. The use of non‐steroidal anti‐inflammatory drugs continues to be limited by their …

Ever since the discovery of aspirin, small molecule therapeutics have been widely
prescribed to treat inflammation and pain. Aspirin and several small molecule NSAIDs are …

Hematopoietic stem cell (HSC) transplantation is a potentially curative treatment for
numerous hematological malignancies. The transplant procedure as performed today takes …

Acyl-CoA: glycerol-3-phosphate acyltransferase (GPAT) catalyzes the first step during de
novo synthesis of glycerolipids. Mammals have at least four GPAT isoforms. Here we report …

The ductus arteriosus is an arterial vessel that shunts blood flow away from the lungs during
fetal life, but normally occludes after birth to establish the adult circulation pattern. Failure of …

Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase activity and hence
PG production. However, the ability of NSAIDs to ameliorate pain and tenderness does not …

Aspirin is now widely accepted as the first-line antithrombotic platelet therapy for at-risk
individuals. During the last decade or so it has also become established that co …

Background and Purpose—The role of brain-derived neurotrophic factor (BDNF) and its
receptor, tropomyosin receptor kinase B, in control of cerebral circulation is poorly …