Obesity is associated with insulin resistance, disturbed glucose homeostasis, low grade
inflammation, and comorbidities such as type 2 diabetes and cardiovascular disease. The …

Matrix metalloproteinases (MMPs, matrixins) are a family of secreted and membrane-bound
zinc-dependent endopeptidases that have the combined capacity to degrade all the …

Abstract Familial Amyloidotic Polyneuropathy (FAP) is a disorder characterized by the
extracellular deposition of fibrillar Transthyretin (TTR) amyloid, with a special involvement of …

We reported that gene-selective formation of facultative heterochromatin silences
transcription of acute inflammatory genes during endotoxin (LPS) tolerance, according to …

Background The sequence of events leading to the development of insulin resistance (IR) as
well as the underlying pathophysiological mechanisms are incompletely understood. As …

OBJECTIVE: There is remarkable controversy over the processes driving abdominal
aneurysm growth. The inherent limitations of animal and human studies hamper elucidation …

Aortic disease is the main cause of death among patients with Marfan syndrome. Before the
development of open surgery, most patients died in the fourth decade of life. Improvements …

OBJECTIVES: We present a method to quantify the inflammatory processes that drive
abdominal aortic aneurysm (AAA) development that may help predict the rate of growth and …

The pathogenesis of aortic aneurysm (AA) is characterized by degradation of extracellular
matrix with increased matrix metalloproteinases (MMPs) and inflammatory reaction …

BACKGROUND: Pharmaceutical stabilisation of the abdominal aortic aneurysm (AAA) wall
can delay surgery and improve outcome. Observational studies indicate statins can be used …