Imaging of lung function using hyperpolarized helium‐3 magnetic resonance imaging: review of current and emerging translational methods and applications

S Fain, ML Schiebler, DG McCormack… - Journal of magnetic …, 2010 - Wiley Online Library
During the past several years there has been extensive development and application of
hyperpolarized helium‐3 (HP 3He) magnetic resonance imaging (MRI) in clinical respiratory …

Assessment of air space size characteristics by intercept (chord) measurement: an accurate and efficient stereological approach

L Knudsen, ER Weibel… - Journal of applied …, 2010 - journals.physiology.org
The mean linear intercept (chord) length (L m) is a useful parameter of peripheral lung
structure as it describes the mean free distance in the air spaces. It is often misinterpreted as …

Chronic Obstructive Pulmonary Disease: Longitudinal Hyperpolarized 3He MR Imaging

M Kirby, L Mathew, A Wheatley, GE Santyr… - Radiology, 2010 - pubs.rsna.org
Purpose To quantitatively evaluate a small pilot group of ex-smokers with chronic obstructive
pulmonary disease (COPD) and healthy volunteers during approximately 2 years by using …

Imaging phenotypes of chronic obstructive pulmonary disease

J Ley‐Zaporozhan… - Journal of Magnetic …, 2010 - Wiley Online Library
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity
and mortality worldwide. COPD is defined by irreversible airflow obstruction. It is a …

Detection of radiation-induced lung injury in non-small cell lung cancer patients using hyperpolarized helium-3 magnetic resonance imaging

RH Ireland, OS Din, JA Swinscoe, N Woodhouse… - Radiotherapy and …, 2010 - Elsevier
PURPOSE: To compare hyperpolarized helium-3 magnetic resonance imaging (3He-MRI)
acquired from non-small cell lung cancer (NSCLC) patients before and after external beam …

On the use of hyperpolarized helium MRI for conformal avoidance lung radiotherapy

CW Hodge, WA Tomé, SB Fain, SM Bentzen… - Medical …, 2010 - Elsevier
We wanted to illustrate the feasibility of using hyperpolarized helium magnetic resonance
imaging (HPH-MRI) to obtain functional information that may assist in improving conformal …

Improved technique for measurement of regional fractional ventilation by hyperpolarized 3He MRI

K Emami, SJ Kadlecek, JM Woodburn… - … in Medicine: An …, 2010 - Wiley Online Library
Quantitative measurement of regional lung ventilation is of great significance in assessment
of lung function in many obstructive and restrictive pulmonary diseases. A new technique for …

Quantitative assessment of lung ventilation and microstructure in an animal model of idiopathic pulmonary fibrosis using hyperpolarized gas MRI

MJ Stephen, K Emami, JM Woodburn, E Chia… - Academic radiology, 2010 - Elsevier
RATIONALE AND OBJECTIVES: The use of hyperpolarized 3He magnetic resonance
imaging as a quantitative lung imaging tool has progressed rapidly in the past decade …

Helium‐3 MR q‐space imaging with radial acquisition and iterative highly constrained back‐projection

RL O'Halloran, JH Holmes, YC Wu… - … in Medicine: An …, 2010 - Wiley Online Library
An undersampled diffusion‐weighted stack‐of‐stars acquisition is combined with iterative
highly constrained back‐projection to perform hyperpolarized helium‐3 MR q‐space …

Hyperpolarized 3He magnetic resonance imaging-derived pulmonary pressure-volume curves

S Choy, A Wheatley… - Journal of Applied …, 2010 - journals.physiology.org
We aimed to evaluate the potential for the use of hyperpolarized helium-3 magnetic
resonance imaging (MRI) apparent diffusion coefficient (ADC) surrogates of alveolar size …