In mammalian cells, elongases and desaturases play critical roles in regulating the length
and degree of unsaturation of fatty acids and thereby their functions and metabolic fates. In …

The peroxisome proliferator‐activated receptor alpha (PPARα) is a ligand‐activated
transcription factor involved in the regulation of a variety of processes, ranging from …

Non-alcoholic fatty liver disease (NAFLD) has a high occurrence in most countries. Recent
studies estimate its prevalence to be near 30% in United States, Italian and Japanese …

Enhanced production of monounsaturated fatty acids (FA) derived from carbohydrate-
enriched diets has been implicated in the development of obesity and insulin resistance …

OBJECTIVE The results of the Diabetes Control and Complications Trial/Epidemiology of
Diabetes Interventions and Complications cohort study revealed a strong association …

Elevated hepatic fatty acid elongase-5 (Elovl5) activity lowers blood glucose in fasted chow-
fed C57BL/6J mice. As high-fat diets induce hyperglycemia and suppress hepatic Elovl5 …

Since liver fatty acid binding protein (L-FABP) facilitates uptake/oxidation of long-chain fatty
acids in cultured transfected cells and primary hepatocytes, loss of L-FABP was expected to …

Successful treatment of obesity and related diseases by chronic food restriction requires the
understanding of the effect of such nutritional therapy on the expression of genes which …

The" lipotoxic footprint" of cardiac maladaptation in diet-induced obesity is poorly defined.
We investigated how manipulation of dietary lipid and carbohydrate influenced potential …

We investigated the effect of a non-mammalian omega-3 desaturase in a mouse
hepatocarcinogenesis model. Mice containing double mutations (DM) in c-myc and TGF-α …