Further studies are needed to identify the specific physiological mechanisms that influence
myosteatosis, and the mechanisms that link this fat depot with insulin resistance …

Intramuscular triacylglycerol (IMTG) is both a dynamic fat-storage depot that can expand
during periods of elevated lipid availability and a fatty acid source that can be utilized during …

Background Sarcopenia often co-exists with obesity, and may have additive effects on
insulin resistance. Sarcopenic obese individuals could be at increased risk for type 2 …

OBJECTIVE We tested the primary hypotheses that sphingolipid and diacylglycerol (DAG)
content is higher within insulin-resistant muscle and that the association between …

Toll-like receptor 4 (TLR4), a protein integral to innate immunity, is elevated in skeletal
muscle of obese and type 2 diabetic humans and has been implicated in the development of …

Background The metabolic syndrome, known also as the insulin resistance syndrome, refers
to the clustering of several risk factors for atherosclerotic cardiovascular disease …

Objective—To determine effects of exercise training without dietary restriction on adiposity,
basal hormone and lipid concentrations and glucose and insulin dynamics in overweight or …

Context: Intracellular lipid partitioning toward storage and the incomplete oxidation of fatty
acids (FA) have been linked to insulin resistance. Objective: To gain insight into how …

Type 2 diabetes mellitus (T2DM) and aging are characterized by insulin resistance and
impaired mitochondrial energetics. In lower organisms, remodeling by the protease pcp1 …

Background Although nonalcoholic fatty liver disease (NAFLD) is associated with visceral
obesity, the relationship between visceral fat accumulation and skeletal muscle steatosis in …