Regulatory activity of polyunsaturated fatty acids in T-cell signaling
n− 3 Polyunsaturated fatty acids (PUFA) are considered to be authentic immunosuppressors
and appear to exert beneficial effects with respect to certain immune-mediated diseases. In …
and appear to exert beneficial effects with respect to certain immune-mediated diseases. In …
The nutritional and clinical significance of lipid rafts
P Yaqoob, SR Shaikh - Current Opinion in Clinical Nutrition & …, 2010 - journals.lww.com
In-vitro and animal studies show that n-3 PUFAs, cholesterol, and gangliosides modulate the
structure and composition of lipid rafts, potentially influencing a wide range of biological …
structure and composition of lipid rafts, potentially influencing a wide range of biological …
[HTML][HTML] n-3 PUFA improves fatty acid composition, prevents palmitate-induced apoptosis, and differentially modifies B cell cytokine secretion in vitro and ex vivo
BD Rockett, M Salameh, K Carraway, K Morrison… - Journal of lipid …, 2010 - ASBMB
n-3 polyunsaturated fatty acids (PUFAs) modify T-cell activation, in part by remodeling lipid
composition; however, the relationship between n-3 PUFA and B-cell activation is unknown …
composition; however, the relationship between n-3 PUFA and B-cell activation is unknown …
Transgenic Mice Enriched in Omega-3 Fatty Acids Are More Susceptible to Pulmonary Tuberculosis: Impaired Resistance to Tuberculosis in fat-1 Mice
DL Bonilla, YY Fan, RS Chapkin… - The Journal of …, 2010 - academic.oup.com
Background. Besides their health benefits, dietary omega-3 fatty acids (n-3 PUFAs) can
impair host resistance to intracellular pathogens. Previously, we and others have showed …
impair host resistance to intracellular pathogens. Previously, we and others have showed …
[HTML][HTML] Incorporation of a Dietary Omega 3 Fatty Acid Impairs Murine Macrophage Responses to Mycobacterium tuberculosis
Background Beside their health benefits, dietary omega 3 polyunsaturated fatty acids (n-3
PUFA) might impair host resistance to Mycobacterium tuberculosis (Mtb) by creating an …
PUFA) might impair host resistance to Mycobacterium tuberculosis (Mtb) by creating an …
n-3 polyunsaturated fatty acids suppress mitochondrial translocation to the immunologic synapse and modulate calcium signaling in T cells
R Yog, R Barhoumi, DN McMurray… - The Journal of …, 2010 - journals.aai.org
Recent studies indicate that the process of Ag presentation induces cytoskeleton-dependent
mitochondrial redistribution to the immediate vicinity of the immunologic synapse (IS). This …
mitochondrial redistribution to the immediate vicinity of the immunologic synapse (IS). This …
Polyunsaturated fatty acids in the modulation of T-cell signalling
NA Khan - Prostaglandins, Leukotrienes and Essential Fatty Acids …, 2010 - Elsevier
n-3 Polyunsaturated fatty acids (PUFA) have been shown to modulate immune responses.
These agents, being considered as adjuvant immunosuppressants, have been used in the …
These agents, being considered as adjuvant immunosuppressants, have been used in the …
Mechanisms underlying the immunomodulatory effects of n-3 PUFA
P Yaqoob - Proceedings of the Nutrition Society, 2010 - cambridge.org
The enrichment of immune cell membranes with n-3 PUFA is associated with modulation of
immune function. The degree of incorporation of n-3 PUFA (and therefore the impact of …
immune function. The degree of incorporation of n-3 PUFA (and therefore the impact of …
Diet-induced docosahexaenoic acid non-raft domains and lymphocyte function
SR Shaikh - Prostaglandins, Leukotrienes and Essential Fatty Acids …, 2010 - Elsevier
Docosahexaenoic acid (DHA) is an n-3 polyunsaturated fatty acid (PUFA) that generally
suppresses the function of T lymphocytes and antigen presenting cells (APCs). An emerging …
suppresses the function of T lymphocytes and antigen presenting cells (APCs). An emerging …
Omega-3 and Omega-6 fatty acids kill thymocytes and increase membrane fluidity
A Prasad, M Åhs, A Goncharov… - The Open Cell …, 2010 - benthamopen.com
Background: Omega-3 but not omega-6 fatty acids are thought to promote cardiovascular
health by increasing membrane fluidity. Methods: The actions of acute application of omega …
health by increasing membrane fluidity. Methods: The actions of acute application of omega …