The integrin family of cell adhesion receptors regulates a diverse array of cellular functions
crucial to the initiation, progression and metastasis of solid tumours. The importance of …

Angiogenesis, or the formation of new blood vessels from the preexisting vasculature, is a
key component in numerous physiologic and pathologic responses and has broad impact in …

Heparanase enhances shedding of syndecan-1 (CD138), and high levels of heparanase
and shed syndecan-1 in the tumor microenvironment are associated with elevated …

Vascular endothelial growth factor A (VEGF‐A)‐induced signaling through VEGF receptor 2
(VEGFR2) regulates both physiological and pathological angiogenesis in mammals …

This review explored the mechanism of breast carcinoma progression by focusing on
integrins and receptor tyrosine kinases (or growth factor receptors). While the primary role of …

Rationale: Integrins cooperate with growth factor receptors to promote downstream signaling
for cell proliferation and migration. However, the mechanism of receptor activation is still …

Extensive infiltration of the surrounding healthy brain tissue is a cardinal feature of
glioblastomas, highly lethal brain tumors. Deep infiltration by the glioblastoma cells renders …

Hantaviruses infect endothelial cells and cause 2 vascular permeability-based diseases.
Pathogenic hantaviruses enhance the permeability of endothelial cells in response to …

Objective—To investigate the capacity of the adipokine leptin to promote angiogenesis by
modulating the function of circulating angiogenic cells (CACs). Methods and Results—In …

Signals generated by the dynamic mechanical strain critically regulate endothelial cell
proliferation and angiogenesis; however, the molecular basis remains unclear. We …