Deregulation of the G1/G0 phase of the cell cycle can lead to cancer. During G1, most cells
commit alternatively to DNA replication and division, or to cell-cycle exit and differentiation …

Meiotic and early-embryonic cell divisions in vertebrates take place in the absence of
transcription and rely on the translational regulation of stored maternal messenger RNAs …

The APC/C (anaphase-promoting complex/cyclosome) discovered exactly 15 years ago by
Avram Heshko and Marc Kirschner is by far the most complex ubiquitin ligase discovered so …

The ubiquitin ligase APC/CCdh1 coordinates degradation of key cell cycle regulators. We
report here that a nuclear-localized portion of the stress-activated kinase JNK is degraded …

Infection of quiescent cells by human cytomegalovirus (HCMV) elicits severe cell cycle
deregulation, resulting in a G1/S arrest, which can be partly attributed to the inactivation of …

The bloodstream form of Trypanosoma brucei differentiates into the stumpy form in the
mammalian bloodstream, completing differentiation into the procyclic form on uptake by the …

In the vertebrate nervous system, neurons often traverse long distances before integrating
into neuronal circuits. The precise control of neuronal morphology and positioning is critical …

In Eukaryotes, cell cycle-dependent protein proteolysis is a hallmark of the cell cycle and is
mediated by the ubiquitin-proteasome pathway. Cdh1 is an important cell cycle regulator …

Ubiquitin-mediated proteolytic degradation is fundamental to eukaryotic cell cycle
progression. From late mitosis through early G1, the Anaphase Promoting Complex (APC) is …