Figure 2. Regulation of the Rho GTPase cycle. Rho protein cycle between an inactive GDP-
bound and an active GTP-bound state. Inhibition of the mevalonate synthesis by statins …

Obesity, a highly prevalent condition, is heterogeneous with regard to its impact on
cardiovascular disease (CVD) risk. Epidemiological observations and metabolic …

Background Homozygous familial hypercholesterolaemia is a rare genetic disorder in which
both LDL-receptor alleles are defective, resulting in very high concentrations of LDL …

Eugen‐Olsen J, Andersen O, Linneberg A, Ladelund S, Hansen TW, Langkilde A, Petersen
J, Pielak T, Møller LN, Jeppesen J, Lyngbæk S, Fenger M, Olsen MH, Hildebrandt PR, Borch …

Objective: We sought to establish reference values for a new direct assay for small dense
LDL cholesterol (sdLDL-C) and to measure sdLDL-C concentrations in patients with …

Inflammation is a classical host defence response to infection and injury that has many
beneficial effects. However, inappropriate (in time, place and magnitude) inflammation is …

C-reactive protein is postulated to embody an index that can reflect cardiovascular risk and
can be used to independently predict major cardiovascular events and mortality. On the …

Background HDL-cholesterol concentrations are inversely associated with occurrence of
cardiovascular events. We addressed, using the JUPITER trial cohort, whether this …

Background: Randomized data on statins for primary prevention in older persons are limited,
and the relative hazard of cardiovascular disease associated with an elevated cholesterol …

Objectives: We evaluated the efficacy of statin therapy in primary prevention among
individuals with moderate chronic kidney disease (CKD). Background: Whether patents with …