Humans possess the remarkable ability to perceive color, shape, and motion, and to
differentiate between light intensities varied by over nine orders of magnitude …

Small populations within an increasing array of solid tumors, labeled cancer stem cells
(CSC) or tumor-initiating cells (TIC), have the ability to differentiate, self-renew, and replicate …

A major cause of the cerebral cortex expansion that occurred during evolution is the
increase in subventricular zone (SVZ) progenitors. We found that progenitors in the outer …

Until now, limitations in the ability to enrich adult NSCs (aNSCs) have hampered meaningful
analysis of these cells at the transcriptome level. Here we show via a split-Cre technology …

Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide.
CD133, a transmembrane glycoprotein, is an important cell surface marker for both stem …

Brain tumors, which are typically very heterogeneous at the cellular level, appear to have a
stem cell foundation. Recently, investigations from multiple groups have found that human …

Tumor initiating or cancer stem cells (CSCs) are suggested to be responsible for tumor
initiation and growth. Moreover, therapy resistance and minimal residual disease are …

Prominin-1 (CD133) is a cholesterol-interacting pentaspan membrane protein concentrated
in plasma membrane protrusions. In epithelial cells, notably neuroepithelial stem cells …

End-stage renal disease (ESRD) is defined as the inability of the kidneys to remove waste
products and excess fluid from the blood. ESRD progresses from earlier stages of chronic …

Glioblastoma multiforme is an extremely aggressive and clinically unresponsive form of
cancer. Transformed neoplastic neural stem cells, resistant to chemotherapy and radiation …