Heterogeneity in endothelial responsiveness to cytokines, molecular causes, and pharmacological consequences

G Molema - Seminars in thrombosis and hemostasis, 2010 - thieme-connect.com
Microvascular endothelial cells play an essential role in inflammatory diseases. Functional
heterogeneity between microvascular segments in normal organ homeostasis has been …

[PDF][PDF] Endothelial cell guidance in 3D patterned scaffolds

Y Aizawa, R Wylie, M Shoichet - Adv Mater, 2010 - academia.edu
A vascular network is required to provide engineered tissue constructs with the oxygen and
nutrients needed for survival.[1, 2] Endothelial cells (ECs), key cellular components of blood …

Extracellular transsulfuration generates hydrogen sulfide from homocysteine and protects endothelium from redox stress

SE Bearden, RS Beard Jr… - American Journal of …, 2010 - journals.physiology.org
Homocysteine, a cardiovascular and neurocognitive disease risk factor, is converted to
hydrogen sulfide, a cardiovascular and neuronal protectant, through the transsulfuration …

Gap junction protein Cx37 interacts with endothelial nitric oxide synthase in endothelial cells

A Pfenniger, JP Derouette, V Verma, X Lin… - … , and vascular biology, 2010 - Am Heart Assoc
Objective—The gap junction protein connexin37 (Cx37) plays an important role in cell-cell
communication in the vasculature. A C1019T Cx37 gene polymorphism, encoding a P319S …

[HTML][HTML] Enoxaparin improves the course of dextran sodium sulfate-induced colitis in syndecan-1-deficient mice

M Floer, M Götte, MK Wild, J Heidemann… - The American journal of …, 2010 - Elsevier
Syndecan-1 (Sdc1) plays a major role in wound healing and modulates inflammatory
responses. Sdc1 expression is reduced in lesions of patients with ulcerative colitis. The aim …

TRPC-mediated actin-myosin contraction is critical for BBB disruption following hypoxic stress

K Hicks, RG O'Neil, WS Dubinsky… - American Journal of …, 2010 - journals.physiology.org
Hypoxia-induced disruption of the blood-brain barrier (BBB) is the result of many different
mechanisms, including alterations to the cytoskeleton. In this study, we identified actin …

Modulation of intracellular Ca2+ concentration in brain microvascular endothelial cells in vitro by acoustic cavitation

J Park, Z Fan, RE Kumon, MEH El-Sayed… - Ultrasound in medicine & …, 2010 - Elsevier
Localized delivery of therapeutic agents through the blood–brain barrier (BBB) is a clinically
significant task that remains challenging. Ultrasound (US) application after intravenous …

Plasminogen activator inhibitor-1 regulates myoendothelial junction formation

KR Heberlein, AC Straub, AK Best… - Circulation …, 2010 - Am Heart Assoc
Rationale: Plasminogen activator inhibitor-1 (PAI-1) is a biomarker for several vascular
disease states; however, its target of action within the vessel wall is undefined. Objective …

Soluble lymphotoxin is an important effector molecule in GVHD and GVL

KA Markey, AC Burman, T Banovic… - Blood, The Journal …, 2010 - ashpublications.org
Tumor necrosis factor (TNF) is a key cytokine in the effector phase of graft-versus-host
disease (GVHD) after bone marrow transplantation, and TNF inhibitors have shown efficacy …

Astrocyte‐derived glutathione attenuates hemin‐induced apoptosis in cerebral microvascular cells

S Sukumari‐Ramesh, MD Laird, N Singh, JR Vender… - Glia, 2010 - Wiley Online Library
Intracerebral hemorrhage (ICH) induces neurovascular injury via poorly defined
mechanisms. The aim of this study was to determine whether gliovascular communication …