Immunological memory is a cardinal feature of adaptive immunity. We are now beginning to
elucidate the mechanisms that govern the formation of memory T cells and their ability to …

Ex vivo generation and antigen loading of dendritic cells (DCs) from cancer patients helps to
bypass the dysfunction of endogenous DCs. It also allows to control the process of DC …

T he current literature on the role of interleukin (IL)-2 in memory CD8+ T-cell differentiation
indicates a significant contribution of IL-2 during primary and also secondary expansion of …

Background CD8+ T cell responses develop rapidly during infection and are swiftly reduced
during contraction, wherein> 90% of primed CD8+ T cells are eliminated. The role of …

CD8 memory T cells can play a critical role in protection against repeated exposure to
infectious agents such as viruses, yet can also contribute to the immunopathology …

An effective immune response to vaccination is, in part, a complex interaction of alleles of
multiple genes regulating cytokine networks. We conducted a genotyping study of …

Several cytokines (including IL-2, IL-7, IL-15, and IL-21) that signal through receptors
sharing the common γ chain (γc) are critical for the generation and peripheral homeostasis …

In the real world, mice and men are not immunologically naive, having been exposed to
numerous antigenic challenges. Prior infections sometimes negatively impact the response …

The requirements for tonic T-cell receptor (TCR) signaling in CD8+ memory T-cell
generation and homeostasis are poorly defined. The SRC homology 2 (SH2)-domain …

Listeria monocytogenes infection induces a strong inflammatory response characterized by
the production of IL-12 and IFN-γ and protective immunity against this pathogen is …