The aims of this article are to summarize existing knowledge regarding the pathophysiology
of small airways disease in cystic fibrosis (CF), to speculate about additional mechanisms …

Mammalian airways are protected from infection by a thin film of airway surface liquid (ASL)
which covers airway epithelial surfaces and acts as a lubricant to keep mucus from adhering …

The airflow characteristics in a computed tomography (CT) based human airway bifurcation
model with rigid and compliant walls are investigated numerically. An in-house three …

The role of cystic fibrosis (CF) transmembrane conductance regulator (CFTR) in airway
epithelial wound repair was investigated using normal human bronchial epithelial (NHBE) …

A balance sheet describing the integrated homeostasis of secretion, absorption, and surface
movement of liquids on pulmonary surfaces has remained elusive. It remains unclear …

Effective clearance of inhaled pathogens is the primary innate defense mechanism in the
lung, and requires the maintenance of a proper airway surface liquid (ASL) volume to …

Lung function is inextricably linked to mechanics. On short timescales every breath
generates dynamic cycles of cell and matrix stretch, along with convection of fluids in the …

Studies in cystic fibrosis patients and mice overexpressing the epithelial Na+ channel β-
subunit (βENaC-Tg) suggest that raised airway Na+ transport and airway surface liquid …

Purinergic regulation of airway innate defence activities is in part achieved by the release of
nucleotides from epithelial cells. However, the mechanisms of airway epithelial nucleotide …

Rationale Airway secretion clearance therapies are a cornerstone of cystic fibrosis care,
however longitudinal comparative studies are rare. Our objectives were to compare three …