Safety and immunotoxicity assessment of immunomodulatory monoclonal antibodies
FR Brennan, LD Morton, S Spindeldreher, A Kiessling… - MAbs, 2010 - Taylor & Francis
Most therapeutic monoclonal antibodies (mAbs) licensed for human use or in clinical
development are indicated for treatment of patients with cancer and inflammatory …
development are indicated for treatment of patients with cancer and inflammatory …
The yin and yang of B cells in graft rejection and tolerance
V Zarkhin, G Chalasani, MM Sarwal - Transplantation reviews, 2010 - Elsevier
Various lineages of B cells are being increasingly recognized as important players in the
etiology and prognosis of both acute and chronic graft rejection. The role of immature …
etiology and prognosis of both acute and chronic graft rejection. The role of immature …
A crucial role for infected-cell/antibody immune complexes in the enhancement of endogenous antiviral immunity by short passive immunotherapy
HA Michaud, T Gomard, L Gros, K Thiolon… - PLoS …, 2010 - journals.plos.org
Antiviral monoclonal antibodies (mAbs) represent promising therapeutics. However, most
mAbs-based immunotherapies conducted so far have only considered the blunting of viral …
mAbs-based immunotherapies conducted so far have only considered the blunting of viral …
Serum antibodies critically affect virus-specific CD4+/CD8+ T cell balance during respiratory syncytial virus infections
D Kruijsen, MJ Bakkers, NO van Uden… - The Journal of …, 2010 - journals.aai.org
Following infection with respiratory syncytial virus (RSV), reinfection in healthy individuals is
common and presumably due to ineffective memory T cell responses. In peripheral blood of …
common and presumably due to ineffective memory T cell responses. In peripheral blood of …
Antinuclear antibodies with nucleosome-restricted specificity for targeted delivery of chemotherapeutic agents
VP Torchilin - Therapeutic Delivery, 2010 - Taylor & Francis
Circulating antinuclear autoantibodies (ANAs) are well known to accompany various
pathological conditions and can be artificially induced by immunization. Research and …
pathological conditions and can be artificially induced by immunization. Research and …
Antibodies in cancer immunotherapy
L Karyampudi, KL Knutson - Cancer Biomarkers, 2010 - content.iospress.com
Monoclonal antibodies are currently being used as potential therapeutics against cancer. So
far, eight monoclonal antibodies have been approved by FDA for human use and all these …
far, eight monoclonal antibodies have been approved by FDA for human use and all these …
Association of polymorphism in FcGR3A gene and progression of low-grade precursor lesions of cervical carcinoma
P Conesa-Zamora, V Santaclara, E Gadea-Niñoles… - Human immunology, 2010 - Elsevier
Polymorphisms in receptors of the constant part of antibodies (FcR) have been associated
with susceptibility to disease and viral infections but have not been studied in cervical …
with susceptibility to disease and viral infections but have not been studied in cervical …
Functional variants of Fc gamma receptor (FCGR2A) and FCGR3A are not associated with susceptibility to systemic sclerosis in a large European Study (EUSTAR)
BZ Alizadeh, J Broen, B Rueda… - The Journal of …, 2010 - jrheum.org
Objective. To investigate the possible role of FCGR2A 519A> G and FCGR3A 559A> C
functional polymorphisms in the genetic predisposition to susceptibility to systemic sclerosis …
functional polymorphisms in the genetic predisposition to susceptibility to systemic sclerosis …
Protection against the allergic airway inflammation depends on the modulation of spleen dendritic cell function and induction of regulatory T cells in mice
Y Wang, C Bai, G Wang, D Wang, X Cheng… - Genetic Vaccines and …, 2010 - Springer
Background Allergen-induced imbalance of specific T regulatory (Treg) cells and T helper 2
cells plays a decisive role in the development of immune response against allergens …
cells plays a decisive role in the development of immune response against allergens …