Antibiotic prescribing in hospitals: a social and behavioural scientific approach

MEJL Hulscher, RPTM Grol… - The Lancet infectious …, 2010 - thelancet.com
Antibiotics have dramatically changed the prognoses of patients with severe infectious
diseases over the past 50 years. However, the emergence and dissemination of resistant …

Comparative Metagenomic Study of Alterations to the Intestinal Microbiota and Risk of Nosocomial Clostridum difficile-Associated Disease

AR Manges, A Labbe, VG Loo… - Journal of Infectious …, 2010 - academic.oup.com
This study investigated the relationship between hospital exposures, intestinal microbiota,
and subsequent risk of Clostridium difficile-associated disease (CDAD), with use of a nested …

Overview of strategies for overcoming the challenge of antimicrobial resistance

P Davey, J Sneddon, D Nathwani - Expert review of clinical …, 2010 - Taylor & Francis
The discovery of penicillin undoubtedly transformed the management of life-threatening
bacterial infections. However, a less comfortable aspect of the antibiotic revolution was that …

Stronger correlation between antibiotic use and the incidence of Clostridium difficile determined by culture results instead of faecal toxin detection only

D Mertz, R Frei, H Plagge, M Battegay… - European journal of …, 2010 - Springer
The detection of Clostridium difficile in previous studies evaluating antibiotic use as a risk
factor was limited to toxin assay tests. The reported associations may have been misleading …

[PDF][PDF] A novel strategy for designing optimal antibiotic stewardships using Clostridium difficile as an exemplar

MA Aldeyab, S Harbarth, N Vernaz, MP Kearney… - hug.ch
Inappropriate antimicrobial use has been associated with increased morbidity, mortality and
hospital costs. As antimicrobial use is considered a major determinant in the evolution of …