Evolutionarily conserved Notch signaling orchestrates diverse physiological mechanisms
during metazoan development and homeostasis. Classically, ligand-activated Notch …

Notch signaling is known to play important roles during retinal development. Recently, Notch
signaling has been shown to be active in proliferating Müller glia in acutely damaged chick …

Abstract 10 years have now passed since the discovery of quiescent neural stem cells within
the mammalian retina. Beside the fascinating aspect of stem cell biology in basic science …

Purpose.: Development of the retinal pigment epithelium (RPE) is controlled by intrinsic and
extrinsic regulators including orthodenticle homeobox 2 (Otx2) and the Wnt/β-catenin …

Background LMO4 is a transcription cofactor expressed during retinal development and in
amacrine neurons at birth. A previous study in zebrafish reported that morpholino RNA …

The distal region of neural retina (ciliary marginal zone [CMZ]) contains stem cells that
produce non‐neural and neuronal progenitors. We provide a detailed gene expression …

Neuropeptides regulate cell-cell signaling and influence many biological processes in
vertebrates, including development, growth, and reproduction. The complex processing of …

Purpose Wnt2b is normally expressed at the optic cup lip and is implicated in ciliary body
induction. The lens has often been considered an organizer for the anterior eye, but recent …

Basic helix–loop–helix (bHLH) transcription factors play important roles in cell type
specification and differentiation during the development of the nervous system. In this study …

Many diseases and/or physical defects due to injury result in the loss of specialized cells
within organ systems and lead to organ system dysfunction. The ultimate goal of cell-based …