Approaches for assessing risks to sensitive populations: lessons learned from evaluating risks in the pediatric population

RN Hines, D Sargent, H Autrup… - Toxicological …, 2010 - academic.oup.com
Assessing the risk profiles of potentially sensitive populations requires a “tool chest” of
methodological approaches to adequately characterize and evaluate these populations. At …

Aflatoxin B1 transfer and metabolism in human placenta

HA Partanen, HS El-Nezami, JM Leppänen… - Toxicological …, 2010 - academic.oup.com
Abstract Aflatoxin B1 (AFB1), a common dietary contaminant, is a major risk factor of
hepatocellular carcinoma (HCC). Early onset of HCC in some countries in Africa and South …

Antimutagenic effects of ethanolic extracts from selected Palestinian medicinal plants

M Khader, N Bresgen, PM Eckl - Journal of ethnopharmacology, 2010 - Elsevier
AIM OF THE STUDY: Eryngium creticum, Nigella sativa, and Teucrium polium have been
traditionally used for the treatment of inflammations, liver disorders, and arthritis. Various …

Prenatal, early life, and childhood exposure to genotoxicants in the living environment

J Katić, A Fučić, M Gamulin - Arhiv za higijenu rada i toksikologiju, 2010 - hrcak.srce.hr
Sažetak Health disorders and diseases related to environmental exposure in children such
as cancer and immunologic disturbances (asthma, allergies) are on the rise. However …

Daño celular en una población infantil potencialmente expuesta a pesticidas

S Benítez-Leite, ML Macchi, V Fernández… - Pediatría …, 2010 - scielo.iics.una.py
Los pesticidas pueden producir efectos agudos o crónicos en la salud humana. Muchos de
ellos pueden provocar daño en el material genético. Esta modificación en la información …

Cytogenetic status in newborns and their parents in Madrid: the BioMadrid study

V Lope, M Pollán, M Fernández… - Environmental and …, 2010 - Wiley Online Library
Monitoring cytogenetic damage is frequently used to assess population exposure to
environmental mutagens. The cytokinesis‐block micronucleus assay is one of the most …

In vivo genotoxicity and stress defences in three flatfish species exposed to CuSO4

H Chairi, C Fernández-Diaz, JI Navas… - Ecotoxicology and …, 2010 - Elsevier
We have used the comet assay to analyse, after 3h, 24h and 6 days, the genotoxic effect in
vivo of applying a single intraperitoneal injection of CuSO4, at a concentration of 2mg/kg, to …

Optimizing urothelial cell preparation for the human urinary micronucleus assay

F Fortin, T Anghel, P Brochu, N Lemieux - Toxicology in Vitro, 2010 - Elsevier
Biological monitoring of early genotoxic effects in urothelial cells using the urinary
micronucleus (MNu) assay is promising for early detection of cancer, such as bladder …

Prenatal PAH exposure is associated with chromosome-specific aberrations in cord blood

MA Orjuela, XH Liu, D Warburton, AL Siebert… - … /Genetic Toxicology and …, 2010 - Elsevier
Chromosomal aberrations are associated with increased cancer risk in adults. Previously,
we demonstrated that stable aberrations involving chromosomes 1–6 in cord blood are …

Assessment of DNA damage in children exposed to indoor tobacco smoke

D Beyoglu, T Ozkozaci, N Akici, GZ Omurtag… - International journal of …, 2010 - Elsevier
The present study is aimed to evaluate the possible DNA damage in children who are living
with smoker parents. The tests were conducted by using alkaline comet assay, measured as …