Circadian clocks align behavioral and biochemical processes with the day/night cycle.
Nearly all vertebrate cells possess self-sustained clocks that couple endogenous rhythms …

Genomics, Type 2 Diabetes, and Obesity | New England Journal of Medicine Skip to main content
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Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …

By combining genome-wide association data from 8,130 individuals with type 2 diabetes
(T2D) and 38,987 controls of European descent and following up previously unidentified …

Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …

Recent genetic mapping and gene-phenotype studies have revealed the genetic
architecture of type 1 diabetes. At least ten genes so far can be singled out as strong causal …

Mitochondrial dysfunction has been observed in skeletal muscle of people with diabetes and
insulin-resistant individuals. Furthermore, inherited mutations in mitochondrial DNA can …

Type 2 diabetes mellitus has been at the forefront of human diseases and phenotypes
studied by new genetic analyses. Thanks to genome‐wide association studies, we have …

OBJECTIVE Glycated hemoglobin (HbA1c), used to monitor and diagnose diabetes, is
influenced by average glycemia over a 2-to 3-month period. Genetic factors affecting …

The discovery of the association between HLA in the major histocompatibility complex
(MHC) on chromosome 6p21 with type 1 diabetes, but not with type 2 diabetes, suggested …