The expanding universe of neurotrophic factors: therapeutic potential in aging and age-associated disorders
Multiple molecular, cellular, structural and functional changes occur in the brain during
aging. Neural cells may respond to these changes adaptively by employing multiple …
aging. Neural cells may respond to these changes adaptively by employing multiple …
Intrathecal NGF administration reduces reactive astrocytosis and changes neurotrophin receptors expression pattern in a rat model of neuropathic pain
G Cirillo, C Cavaliere, MR Bianco, A De Simone… - Cellular and molecular …, 2010 - Springer
Nerve growth factor (NGF), an essential peptide for sensory neurons, seems to have
opposite effects when administered peripherally or directly to the central nervous system …
opposite effects when administered peripherally or directly to the central nervous system …
Новые низкомолекулярные миметики фактора роста нервов
ТА Гудашева, ТА Антипова, СБ Середенин - Доклады академии наук, 2010 - elibrary.ru
ГУДАШЕВА и др. логом предшествующего этому фрагменту Lys32. Синтезирован
мономерный (NН2–(СН2) 5–СО–Gly–Lys–NH2, ГК 5) и гомодимерный ((NН2–(СН2) 5 …
мономерный (NН2–(СН2) 5–СО–Gly–Lys–NH2, ГК 5) и гомодимерный ((NН2–(СН2) 5 …
Novel low-molecular-weight mimetics of the nerve growth factor
TA Gudasheva, TA Antipova… - Doklady. Biochemistry …, 2010 - search.proquest.com
After the discovery of the nerve growth factor (NGF) in 1952, its involvement in the regulation
of growth, differentiation, and survival of neurons was convincingly demonstrated. NGF …
of growth, differentiation, and survival of neurons was convincingly demonstrated. NGF …
Discriminative behavioral assessment unveils remarkable reactive astrocytosis and early molecular correlates in basal ganglia of 3-nitropropionic acid subchronic …
G Cirillo, N Maggio, MR Bianco, C Vollono… - Neurochemistry …, 2010 - Elsevier
Reactive astrocytosis seems to be strongly implicated in the development and maintenance
of inflammatory and neurodegenerative disorders. We design a new toxic model treatment …
of inflammatory and neurodegenerative disorders. We design a new toxic model treatment …
[PDF][PDF] Role of the conformational versatility of the neurotrophin N-terminal regions in their recognition by Trk receptors
Neurotrophins (NTs) represent a family of proteins that play an important role in the survival,
development, and function of neurons. Extensive efforts are currently being made to develop …
development, and function of neurons. Extensive efforts are currently being made to develop …
短肽类药物与中枢神经系统疾病
孟玮， 顾兵 - 中国药理学通报, 2010 - cqvip.com
中枢神经系统疾病的治疗一直是医学领域的难题. 传统药物无法防治急慢性中枢神经系统损伤,
阿尔采末病, 帕金森病, 癫痫等中枢神经系统疾病. 医学界一直在致力于寻找治疗中枢神经系统 …
阿尔采末病, 帕金森病, 癫痫等中枢神经系统疾病. 医学界一直在致力于寻找治疗中枢神经系统 …
Neurotrophic Factors as Novel Therapeutic Targets
SD Skaper - Pharmaceutical Sciences Encyclopedia: Drug …, 2010 - Wiley Online Library
It has long been hoped that the power of neurotrophic factors to regulate neuronal cell
survival in the developing nervous system could be harnessed for the treatment of …
survival in the developing nervous system could be harnessed for the treatment of …