Liver ischemia/reperfusion (IR) injury is typified by an inflammatory response.
Understanding the cellular and molecular events underpinning this inflammation is …

BACKGROUND Uterus transplantation (UTx) is developed in animal models as a future
method to treat uterine factor infertility. METHODS All published studies in the area of UTx …

Endogenous ligands such as high‐mobility group box 1 (HMGB1) and nucleic acids are
released by dying cells and bind Toll‐like receptors (TLRs). Because TLR9 sits at the …

TLRs are recognized as promoters of tissue damage, even in the absence of pathogens.
TLR binding to damage-associated molecular patterns (DAMPs) released by injured host …

Increasing evidence shows that reactive oxygen species (ROS) may be critical mediators of
liver damage during the relative hypoxia of ischemia/reperfusion injury (IRI) associated with …

Mitochondria play key roles in aerobic life and in cell death. Thus, interference of normal
mitochondrial function impairs cellular energy and lipid metabolism and leads to the …

Abstract Background/Aims Acute hyperglycemia is known to worsen ischemia/reperfusion
(I/R) injury following myocardial infarction and stroke. We investigated whether acute …

HMGB1, an evolutionarily conserved chromosomal protein, was recently re-discovered to
act as a “danger signal”(alarmin) to alert the innate immune system for the initiation of host …

Abstract Programmed death‐1 (PD‐1)/B7‐H1 costimulation acts as a negative regulator of
host alloimmune responses. Although CD4 T cells mediate innate immunity‐dominated …

Cholestatic liver disease causes significant morbidity and mortality in children. The
diagnosis and management of these diseases can be complicated by an inability to detect …